In situ proximity of CX3CR1-positive mononuclear phagocytes and VIP-ergic nerve fibers suggests VIP-ergic immunomodulation in the mouse ileum

Being continuously exposed to a plethora of antigens ranging from food antigens to potential pathogenic organisms, the gastrointestinal (GI) tract harbors the largest collection of immune cells in the mammalian body. This immune system has to maintain a delicate balance between mounting an active im...

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Veröffentlicht in:	Cell and tissue research 2017-06, Vol.368 (3), p.459-467
Hauptverfasser:	Buckinx, Roeland, Alpaerts, Katrien, Pintelon, Isabel, Cools, Nathalie, Van Nassauw, Luc, Adriaensen, Dirk, Timmermans, Jean-Pierre
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens Biomedical and Life Sciences Biomedicine Chains (polymeric) Chemokine CX3CL1 - metabolism Communications systems Continuous fiber composites CX3CR1 protein Dendritic cells Enteric nervous system Fibers Food Gastrointestinal system Gastrointestinal tract Human Genetics Ileum Ileum - immunology Ileum - innervation Ileum - metabolism Ileum - ultrastructure Immune response Immunoelectron microscopy Immunofluorescence Immunological tolerance Immunomodulation Innervation Intestine Lamina propria Leukocytes (mononuclear) Macrophages Mice Mice, Inbred C57BL Microscopy Molecular Medicine Mononuclear Phagocyte System - metabolism Mounting Nerve Fibers - metabolism Nervous system Neuroimmunomodulation Phagocytes Polymerase chain reaction Proteomics Proximity Receptors, Vasoactive Intestinal Polypeptide, Type I - metabolism Regular Article Reverse transcription Rodents Signal Transduction Vasoactive agents Vasoactive intestinal peptide Vasoactive Intestinal Peptide - metabolism Vasoactive intestinal peptides
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