Discovery and dimeric approach of novel Natriuretic Peptide Receptor A (NPR-A) agonists

[Display omitted] Novel agonists of the Natriuretic Peptide Receptor A (NPR-A) were obtained through random screening and subsequent structural modification of triazine derivatives. The key structural feature to improve in vitro activity was the dimerization of triazine monomer derivatives. The non...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2017-03, Vol.25 (6), p.1762-1769
Hauptverfasser:	Iwaki, Takehiko, Oyama, Yoshiaki, Tomoo, Toshiyuki, Tanaka, Taisaku, Okamura, Yoshihiko, Sugiyama, Masako, Yamaki, Akira, Furuya, Mayumi
Format:	Artikel
Sprache:	eng
Schlagworte:	Agonist Animals Congestive heart failure Crystallography, X-Ray Cyclic GMP - metabolism Dimerization Diuretics - pharmacology Drug Discovery Humans Kidney - drug effects Kidney - metabolism Male Mass Spectrometry - methods Molecular Structure Natriuretic Peptide Receptor A Proton Magnetic Resonance Spectroscopy Rats Rats, Sprague-Dawley Receptors, Atrial Natriuretic Factor - agonists Structure-Activity Relationship Triazine derivatives Triazines - chemistry Triazines - pharmacology
Online-Zugang:	Volltext
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