Age-related microglial activation in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic neurodegeneration in C57BL/6 mice

Microglial activation was investigated in the brains of young (3 months old) and older (9–12 months old) mice following administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Tyrosine hydroxylase (TH)-positive neuronal loss differed significantly between young and older mice. Importa...

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Veröffentlicht in:	Brain research 2003-02, Vol.964 (2), p.288-294
Hauptverfasser:	Sugama, Shuei, Yang, Lichuan, Cho, Byung Pil, DeGiorgio, Lorraine A, Lorenzl, Stefan, Albers, David S, Beal, M.Flint, Volpe, Bruce T, Joh, Tong H
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Aging Animals Biological and medical sciences C57BL/6 mouse Cell Count Cell Death Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Disease Models, Animal Dopamine - metabolism Dopamine Agents Dopaminergic neurodegeneration Immunohistochemistry Male Medical sciences Mice Mice, Inbred C57BL Microglia - enzymology Microglia - metabolism Microglial activation MPTP Nerve Degeneration - chemically induced Nerve Degeneration - enzymology Nerve Degeneration - metabolism Neurology Neurons - metabolism Parkinson Disease - metabolism Substantia Nigra - enzymology Substantia Nigra - metabolism Time Factors Tyrosine 3-Monooxygenase - metabolism
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