Stat3 activation regulates the expression of vascular endothelial growth factor and human pancreatic cancer angiogenesis and metastasis

Expression of vascular endothelial growth factor (VEGF), a key angiogenic protein, has been linked with pancreatic cancer progression. However, the molecular basis for VEGF overexpression remains unclear. Immunohistochemical studies have indicated that VEGF overexpression coincides with elevated Sta...

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Veröffentlicht in:	Oncogene 2003-01, Vol.22 (3), p.319-329
Hauptverfasser:	Wei, Daoyan, Le, Xiangdong, Zheng, Leizhen, Wang, Liwei, Frey, Jennifer A, Gao, Allen C, Peng, Zhihai, Huang, Suyun, Xiong, Henry Q, Abbruzzese, James L, Xie, Keping
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - genetics Adenocarcinoma - metabolism Adenocarcinoma - pathology Animals Apoptosis Biological and medical sciences Carcinogenicity Tests Cell Biology Cell Nucleus - metabolism Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Down-Regulation Endothelial Growth Factors - genetics Endothelial Growth Factors - metabolism Female Fundamental and applied biological sciences. Psychology Gene Expression Regulation Genes, Dominant Human Genetics Humans Intercellular Signaling Peptides and Proteins - genetics Intercellular Signaling Peptides and Proteins - metabolism Internal Medicine Liver Neoplasms - secondary Lymphokines - genetics Lymphokines - metabolism Medicine Medicine & Public Health Mice Mice, Inbred BALB C Molecular and cellular biology Neovascularization, Pathologic Oncology original-paper Pancreas - blood supply Pancreatic cancer Pancreatic Neoplasms - genetics Pancreatic Neoplasms - metabolism Pancreatic Neoplasms - pathology Promoter Regions, Genetic Signal Transduction STAT3 Transcription Factor Trans-Activators - genetics Trans-Activators - metabolism Tumor Cells, Cultured Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factors
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