Chronic inhibition of the norepinephrine transporter in the brain participates in seizure sensitization to cocaine and local anesthetics

The involvement of chronic inhibition of monoamine transporters (MAT) in the brain with respect to sensitization to cocaine- and local anesthetic-induced seizures was studied in mice. Repeated administration of subconvulsive doses of meprylcaine as well as cocaine, both of which inhibit MAT, but not...

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Veröffentlicht in:	Brain research 2003-02, Vol.964 (1), p.83-90
Hauptverfasser:	Arai, Shigeaki, Morita, Katsuya, Kitayama, Shigeo, Kumagai, Kei, Kumagai, Michio, Kihira, Kenji, Dohi, Toshihiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic Uptake Inhibitors Anesthetics, Local - adverse effects Animals Biological and medical sciences Brain - drug effects Brain - metabolism Brain - physiopathology Brain Chemistry - drug effects Brain Chemistry - physiology Citalopram - pharmacology Cocaine Cocaine - adverse effects Desipramine - pharmacology Dopamine Uptake Inhibitors - pharmacology Dose-Response Relationship, Drug Drug toxicity and drugs side effects treatment Inhibition of monoamine transporter Kindling Lidocaine - pharmacology Local anesthetic Male Maprotiline - pharmacology Medical sciences Mice Mice, Inbred ICR Norepinephrine Plasma Membrane Transport Proteins Pharmacology. Drug treatments Piperazines - pharmacology Seizure Seizures - chemically induced Seizures - metabolism Seizures - physiopathology Serotonin Uptake Inhibitors - pharmacology Symporters - drug effects Symporters - metabolism Time Factors Toxicity: nervous system and muscle
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