An in vivo microdialysis method for the qualitative analysis of hepatic phase I metabolites of phenol in rainbow trout ( Oncorhynchus mykiss)

Development of reliable and accurate methodologies for determination of xenobiotic hepatic biotransformation rate and capacity parameters is important to the derivation of precise physiologically-based toxicokinetic (PB-TK) models. Biotransformation data incorporated into PB-TK models has, for the m...

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Veröffentlicht in:	Aquatic toxicology 2003-02, Vol.62 (4), p.337-347
Hauptverfasser:	Solem, Laura E, Kolanczyk, Richard C, McKim, James M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal, plant and microbial ecology Animals Applied ecology Biological and medical sciences Biotransformation Catechols - chemistry Dialysis - methods Disinfectants - metabolism Ecotoxicology, biological effects of pollution Effects of pollution and side effects of pesticides on protozoa and invertebrates Fundamental and applied biological sciences. Psychology Hydroquinone Hydroquinones - chemistry Liver Metabolism Microdialysis Models, Theoretical Oncorhynchus mykiss Oncorhynchus mykiss - physiology Phenol Phenol - metabolism Rainbow trout Reproducibility of Results Techniques Xenobiotics - metabolism
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