AND logic-like pH- and light-dual controlled drug delivery by surface modified mesoporous silica nanoparticles
Recently, the controlled drug delivery system has become a potential platform for biomedical application. Herein, we developed a pH and light-dual controlled cargo release system exhibiting AND logic based on MCM-41 mesoporous silica nanoparticles, which was surface modified using β-cyclodextrin (β-...
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| Veröffentlicht in: | Materials Science & Engineering C 2017-04, Vol.73, p.1-7 |
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| creator | Zhao, Junwei He, Zhaoshuai Li, Biao Cheng, Tanyu Liu, Guohua |
| description | Recently, the controlled drug delivery system has become a potential platform for biomedical application. Herein, we developed a pH and light-dual controlled cargo release system exhibiting AND logic based on MCM-41 mesoporous silica nanoparticles, which was surface modified using β-cyclodextrin (β-CD) with imine bond and azobenzene derivative. The complex of β-CD and azobenzene derivative effectively blocked the cargo delivery in pH=7.0 phosphate buffered saline (PBS) solution without 365nm UV light irradiation. The cargo was fully released when both factors of acidic environment (pH=5.0 PBS) and 365nm UV light irradiation were satisfied, meanwhile only very little cargo was delivered if one factor was satisfied. The result also demonstrates that the opening/closing of the gate and the release of the cargo in small portions can be controlled.
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•A pH and light-dual controlled cargo release system exhibiting AND logic is developed.•The delivery system can release the cargo in small potions by controlling the opening/closing of the gate.•The delivery system realizes the controlled release in zebrafish. |
| doi_str_mv | 10.1016/j.msec.2016.12.056 |
| format | Article |
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[Display omitted]
•A pH and light-dual controlled cargo release system exhibiting AND logic is developed.•The delivery system can release the cargo in small potions by controlling the opening/closing of the gate.•The delivery system realizes the controlled release in zebrafish.</description><identifier>ISSN: 0928-4931</identifier><identifier>EISSN: 1873-0191</identifier><identifier>DOI: 10.1016/j.msec.2016.12.056</identifier><identifier>PMID: 28183586</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Adsorption ; Animals ; Biomedical materials ; Cargo ; Cyclodextrins ; Delayed-Action Preparations ; Drug delivery ; Drug Delivery Systems ; Hydrogen ions ; Hydrogen-Ion Concentration ; Irradiation ; Kinetics ; Light ; Light irradiation ; Logic ; Magnetic Resonance Spectroscopy ; Materials science ; Mesoporous material ; Nanoparticle ; Nanoparticles ; Nanoparticles - chemistry ; Nitrogen - chemistry ; pH effects ; pH-sensitive ; Phosphates ; Photosensitive ; Porosity ; Scattering, Small Angle ; Silica ; Silicon dioxide ; Silicon Dioxide - chemistry ; Spectrophotometry, Ultraviolet ; Spectroscopy, Fourier Transform Infrared ; Surface Properties ; Temperature ; Ultraviolet radiation ; X-Ray Diffraction ; Zebrafish ; β-Cyclodextrin</subject><ispartof>Materials Science & Engineering C, 2017-04, Vol.73, p.1-7</ispartof><rights>2016 Elsevier B.V.</rights><rights>Copyright © 2016 Elsevier B.V. All rights reserved.</rights><rights>Copyright Elsevier BV Apr 1, 2017</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c384t-5baea38b4533a9741707a091802012ae65f51fe22c6a91386df3637c1b92deb43</citedby><cites>FETCH-LOGICAL-c384t-5baea38b4533a9741707a091802012ae65f51fe22c6a91386df3637c1b92deb43</cites><orcidid>0000-0003-2088-415X ; 0000-0002-5245-814X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.msec.2016.12.056$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28183586$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhao, Junwei</creatorcontrib><creatorcontrib>He, Zhaoshuai</creatorcontrib><creatorcontrib>Li, Biao</creatorcontrib><creatorcontrib>Cheng, Tanyu</creatorcontrib><creatorcontrib>Liu, Guohua</creatorcontrib><title>AND logic-like pH- and light-dual controlled drug delivery by surface modified mesoporous silica nanoparticles</title><title>Materials Science & Engineering C</title><addtitle>Mater Sci Eng C Mater Biol Appl</addtitle><description>Recently, the controlled drug delivery system has become a potential platform for biomedical application. Herein, we developed a pH and light-dual controlled cargo release system exhibiting AND logic based on MCM-41 mesoporous silica nanoparticles, which was surface modified using β-cyclodextrin (β-CD) with imine bond and azobenzene derivative. The complex of β-CD and azobenzene derivative effectively blocked the cargo delivery in pH=7.0 phosphate buffered saline (PBS) solution without 365nm UV light irradiation. The cargo was fully released when both factors of acidic environment (pH=5.0 PBS) and 365nm UV light irradiation were satisfied, meanwhile only very little cargo was delivered if one factor was satisfied. The result also demonstrates that the opening/closing of the gate and the release of the cargo in small portions can be controlled.
[Display omitted]
•A pH and light-dual controlled cargo release system exhibiting AND logic is developed.•The delivery system can release the cargo in small potions by controlling the opening/closing of the gate.•The delivery system realizes the controlled release in zebrafish.</description><subject>Adsorption</subject><subject>Animals</subject><subject>Biomedical materials</subject><subject>Cargo</subject><subject>Cyclodextrins</subject><subject>Delayed-Action Preparations</subject><subject>Drug delivery</subject><subject>Drug Delivery Systems</subject><subject>Hydrogen ions</subject><subject>Hydrogen-Ion Concentration</subject><subject>Irradiation</subject><subject>Kinetics</subject><subject>Light</subject><subject>Light irradiation</subject><subject>Logic</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Materials science</subject><subject>Mesoporous material</subject><subject>Nanoparticle</subject><subject>Nanoparticles</subject><subject>Nanoparticles - chemistry</subject><subject>Nitrogen - chemistry</subject><subject>pH effects</subject><subject>pH-sensitive</subject><subject>Phosphates</subject><subject>Photosensitive</subject><subject>Porosity</subject><subject>Scattering, Small Angle</subject><subject>Silica</subject><subject>Silicon dioxide</subject><subject>Silicon Dioxide - chemistry</subject><subject>Spectrophotometry, Ultraviolet</subject><subject>Spectroscopy, Fourier Transform Infrared</subject><subject>Surface Properties</subject><subject>Temperature</subject><subject>Ultraviolet radiation</subject><subject>X-Ray Diffraction</subject><subject>Zebrafish</subject><subject>β-Cyclodextrin</subject><issn>0928-4931</issn><issn>1873-0191</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kUFv1DAQhS0EotvCH-CALHHhkuCxE8eRuFQFWqQKLnC2HHuyeHHiYCeV9t_j1RYOHDjNHL73NPMeIa-A1cBAvjvUU0Zb87LXwGvWyidkB6oTFYMenpId67mqml7ABbnM-cCYVKLjz8kFV6BEq-SOzNdfPtAQ995Wwf9EutxV1MyOBr__sVZuM4HaOK8phoCOurTtqcPgHzAd6XCkeUujsUin6PzoCzFhjktMccs0--CtobOZ42LS6m3A_II8G03I-PJxXpHvnz5-u7mr7r_efr65vq-sUM1atYNBI9TQtEKYvmugY51hPShWnuUGZTu2MCLnVpoehJJuFFJ0FoaeOxwacUXenn2XFH9tmFc9-WwxBDNjuU2Dkl3bcNGpgr75Bz3ELc3lOg19w7umbQQUip8pm2LOCUe9JD-ZdNTA9KkNfdCnNvSpDQ1clzaK6PWj9TZM6P5K_sRfgPdnAEsWDx6TztbjbNH5hHbVLvr_-f8Gh9Ga8w</recordid><startdate>20170401</startdate><enddate>20170401</enddate><creator>Zhao, Junwei</creator><creator>He, Zhaoshuai</creator><creator>Li, Biao</creator><creator>Cheng, Tanyu</creator><creator>Liu, Guohua</creator><general>Elsevier B.V</general><general>Elsevier BV</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7T7</scope><scope>7TA</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>JG9</scope><scope>JQ2</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-2088-415X</orcidid><orcidid>https://orcid.org/0000-0002-5245-814X</orcidid></search><sort><creationdate>20170401</creationdate><title>AND logic-like pH- and light-dual controlled drug delivery by surface modified mesoporous silica nanoparticles</title><author>Zhao, Junwei ; 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Herein, we developed a pH and light-dual controlled cargo release system exhibiting AND logic based on MCM-41 mesoporous silica nanoparticles, which was surface modified using β-cyclodextrin (β-CD) with imine bond and azobenzene derivative. The complex of β-CD and azobenzene derivative effectively blocked the cargo delivery in pH=7.0 phosphate buffered saline (PBS) solution without 365nm UV light irradiation. The cargo was fully released when both factors of acidic environment (pH=5.0 PBS) and 365nm UV light irradiation were satisfied, meanwhile only very little cargo was delivered if one factor was satisfied. The result also demonstrates that the opening/closing of the gate and the release of the cargo in small portions can be controlled.
[Display omitted]
•A pH and light-dual controlled cargo release system exhibiting AND logic is developed.•The delivery system can release the cargo in small potions by controlling the opening/closing of the gate.•The delivery system realizes the controlled release in zebrafish.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>28183586</pmid><doi>10.1016/j.msec.2016.12.056</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0003-2088-415X</orcidid><orcidid>https://orcid.org/0000-0002-5245-814X</orcidid></addata></record> |
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| subjects | Adsorption Animals Biomedical materials Cargo Cyclodextrins Delayed-Action Preparations Drug delivery Drug Delivery Systems Hydrogen ions Hydrogen-Ion Concentration Irradiation Kinetics Light Light irradiation Logic Magnetic Resonance Spectroscopy Materials science Mesoporous material Nanoparticle Nanoparticles Nanoparticles - chemistry Nitrogen - chemistry pH effects pH-sensitive Phosphates Photosensitive Porosity Scattering, Small Angle Silica Silicon dioxide Silicon Dioxide - chemistry Spectrophotometry, Ultraviolet Spectroscopy, Fourier Transform Infrared Surface Properties Temperature Ultraviolet radiation X-Ray Diffraction Zebrafish β-Cyclodextrin |
| title | AND logic-like pH- and light-dual controlled drug delivery by surface modified mesoporous silica nanoparticles |
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