Chromatin priming of genes in development: concepts, mechanisms and consequences
Abstract During ontogeny, cells progress through multiple alternate differentiation states by activating distinct gene regulatory networks. In this review we highlight the important role of chromatin priming in facilitating gene activation during lineage specification and in maintaining an epigeneti...
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| Veröffentlicht in: | Experimental hematology 2017-05, Vol.49, p.1-8 |
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| container_title | Experimental hematology |
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| creator | Bonifer, Constanze Cockerill, Peter N |
| description | Abstract During ontogeny, cells progress through multiple alternate differentiation states by activating distinct gene regulatory networks. In this review we highlight the important role of chromatin priming in facilitating gene activation during lineage specification and in maintaining an epigenetic memory of previous gene activation. We describe that chromatin priming is part of a hugely diverse repertoire of regulatory mechanisms that genes use to ensure that they are expressed at the correct time, in the correct cell type, at the correct level, but also that they react to signals. We also emphasize how increasing our knowledge of these principles could inform our understanding of developmental failure and disease. |
| doi_str_mv | 10.1016/j.exphem.2017.01.003 |
| format | Article |
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| ispartof | Experimental hematology, 2017-05, Vol.49, p.1-8 |
| issn | 0301-472X 1873-2399 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Advanced Basic Science Animals Chromatin - genetics Chromatin - metabolism Epigenesis, Genetic - physiology Gene Regulatory Networks - physiology Hematology, Oncology and Palliative Medicine Humans |
| title | Chromatin priming of genes in development: concepts, mechanisms and consequences |
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