Palmitic acid stimulates interleukin‐8 via the TLR4/NF‐κB/ROS pathway and induces mitochondrial dysfunction in bovine oviduct epithelial cells

Problem We investigated the effect of palmitic acid (PA), a major saturated fatty acid in NEFA, on bovine oviduct epithelial cells (OECs) during in vitro cell culture. Method of study Bovine oviductal tissues ipsilateral to the corpus luteum were collected 1‐3 days after ovulation; the OECs were iso...

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Veröffentlicht in:	American journal of reproductive immunology (1989) 2017-06, Vol.77 (6), p.n/a
Hauptverfasser:	Ohtsu, Ayaka, Tanaka, Hazuki, Seno, Kotomi, Iwata, Hisataka, Kuwayama, Takehito, Shirasuna, Koumei
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - metabolism Animals autophagy bovine Caspase 3 - metabolism Cattle Cell Proliferation - drug effects Cell Survival - drug effects Cells, Cultured Epithelial Cells - drug effects Epithelial Cells - metabolism Female inflammation Interleukin-8 - metabolism Mitochondria - drug effects Mitochondria - metabolism mitochondrial fission NF-kappa B - metabolism oviduct epithelial cells Oviducts - cytology Palmitic Acid - pharmacology Reactive Oxygen Species - metabolism Toll-Like Receptor 4 - metabolism
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