Expression of polysialic acid in primary laryngeal squamous cell carcinoma

Expression of polySia is associated with metastatic dissemination and progression of various malignant diseases. In particular, it may contribute to tumorigenesis by a negative modulatory effect on cellular signaling cascades responsible for cellular migration, differentiation and proliferation. In...

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Veröffentlicht in:	Life sciences (1973) 2017-03, Vol.173, p.73-79
Hauptverfasser:	Klobučar, Marko, Visentin, Sarah, Jakovčević, Antonija, Bilić, Mario, Kovač-Bilić, Lana, Đanić, Davorin, Pavelić, Krešimir, Kraljević Pavelić, Sandra
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Biopsy Cancer Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - pathology Cascades Differentiation (biology) Extracellular signal-regulated kinase FGFR-MAPK/Erk1/2 signaling Fibroblast growth factor receptor 1 Gene Expression Regulation, Neoplastic Humans Immunohistochemistry Kinases Laryngeal Neoplasms - metabolism Laryngeal Neoplasms - pathology Laryngeal squamous cell carcinoma Male Metastases Metastasis Middle Aged Neoplasm Metastasis Neoplasm Proteins - biosynthesis Polysialic acid Polysialyltransferase Raf protein Sialic Acids - biosynthesis Sialyltransferases - biosynthesis Squamous cell carcinoma Tissues Tumor Cells, Cultured Tumorigenesis Tumors
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