Microtubule-associated protein 1S-related autophagy inhibits apoptosis of intestinal epithelial cells via Wnt/β-catenin signaling in Crohn's disease

Many autophagy-related genes, to our knowledge, have been identified as Crohn's disease (CD) polymorphic sites by genomic wide studies. As a novel member of the microtubule-associated protein 1 (MAP1) family, MAP1S is a microtubule-binding proteins involved in autophagy. However, its expression...

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Veröffentlicht in:	Biochemical and biophysical research communications 2017-04, Vol.485 (3), p.635-642
Hauptverfasser:	Bai, Wenxia, Bai, Jian'an, Li, Yanhai, Tian, Delong, Shi, Ruihua
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Apoptosis - physiology Autophagy Autophagy - physiology Benzothiazoles - pharmacology Blotting, Western Caspase 3 - metabolism Cells, Cultured Colitis - chemically induced Colitis - genetics Colitis - metabolism Crohn Disease - genetics Crohn Disease - metabolism Crohn's disease Epithelial Cells - metabolism HCT116 Cells Humans Immunohistochemistry Intestinal Mucosa - metabolism Intestinal Mucosa - pathology MAP1S Mice Microscopy, Confocal Microtubule-Associated Proteins - genetics Microtubule-Associated Proteins - metabolism RNA Interference Trinitrobenzenesulfonic Acid Wnt Signaling Pathway - drug effects Wnt Signaling Pathway - physiology Wnt/β-catenin
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