Effect of posture on lung ventilation distribution and associations with structure in children with cystic fibrosis
Abstract Background We assessed the effect of posture on ventilation distribution and the impact on associations with structural lung disease. Methods Multiple breath washout (MBW) was performed in seated and supine postures in 25 healthy children and 21 children with CF. Children with CF also under...
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| Veröffentlicht in: | Journal of cystic fibrosis 2017-11, Vol.16 (6), p.713-718 |
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| creator | Ramsey, Kathryn A McGirr, Caroline Stick, Stephen M Hall, Graham L Simpson, Shannon J |
| description | Abstract Background We assessed the effect of posture on ventilation distribution and the impact on associations with structural lung disease. Methods Multiple breath washout (MBW) was performed in seated and supine postures in 25 healthy children and 21 children with CF. Children with CF also underwent a chest CT scan. Functional residual capacity (FRC), lung clearance index (LCI) and moment ratios were calculated from the MBW test. CT scans were evaluated for CF-related structural lung disease. Results FRC was lower in the supine than in the seated posture, whereas LCI was higher in the supine than in the seated posture. In children with CF, associations between LCI and the extent of structural lung disease were stronger when performed in the supine posture. Conclusions Body posture influences lung volumes and ventilation distribution in both healthy children and children with CF. MBW testing in the supine posture strengthened associations with structural lung damage. |
| doi_str_mv | 10.1016/j.jcf.2017.01.013 |
| format | Article |
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Methods Multiple breath washout (MBW) was performed in seated and supine postures in 25 healthy children and 21 children with CF. Children with CF also underwent a chest CT scan. Functional residual capacity (FRC), lung clearance index (LCI) and moment ratios were calculated from the MBW test. CT scans were evaluated for CF-related structural lung disease. Results FRC was lower in the supine than in the seated posture, whereas LCI was higher in the supine than in the seated posture. In children with CF, associations between LCI and the extent of structural lung disease were stronger when performed in the supine posture. Conclusions Body posture influences lung volumes and ventilation distribution in both healthy children and children with CF. MBW testing in the supine posture strengthened associations with structural lung damage.</description><identifier>ISSN: 1569-1993</identifier><identifier>EISSN: 1873-5010</identifier><identifier>DOI: 10.1016/j.jcf.2017.01.013</identifier><identifier>PMID: 28188011</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Adolescent ; Biomechanical Phenomena - physiology ; Child ; Computed tomography ; Cystic fibrosis ; Cystic Fibrosis - diagnosis ; Cystic Fibrosis - physiopathology ; Female ; Functional Residual Capacity - physiology ; Humans ; Lung - physiopathology ; Lung clearance index ; Male ; Mucociliary Clearance - physiology ; Multiple breath washout ; Posture ; Posture - physiology ; Pulmonary Ventilation - physiology ; Pulmonary/Respiratory ; Respiratory Function Tests - methods ; Tomography, X-Ray Computed - methods ; Ventilation distribution</subject><ispartof>Journal of cystic fibrosis, 2017-11, Vol.16 (6), p.713-718</ispartof><rights>European Cystic Fibrosis Society.</rights><rights>2017 European Cystic Fibrosis Society</rights><rights>Copyright © 2017 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c451t-e99c53b9c13b54996ea5b783a4b1ab223ca55d1088f3ad9ed51e39c9c350f67f3</citedby><cites>FETCH-LOGICAL-c451t-e99c53b9c13b54996ea5b783a4b1ab223ca55d1088f3ad9ed51e39c9c350f67f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1569199317300206$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28188011$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ramsey, Kathryn A</creatorcontrib><creatorcontrib>McGirr, Caroline</creatorcontrib><creatorcontrib>Stick, Stephen M</creatorcontrib><creatorcontrib>Hall, Graham L</creatorcontrib><creatorcontrib>Simpson, Shannon J</creatorcontrib><creatorcontrib>on behalf of AREST CF</creatorcontrib><creatorcontrib>AREST CF</creatorcontrib><title>Effect of posture on lung ventilation distribution and associations with structure in children with cystic fibrosis</title><title>Journal of cystic fibrosis</title><addtitle>J Cyst Fibros</addtitle><description>Abstract Background We assessed the effect of posture on ventilation distribution and the impact on associations with structural lung disease. Methods Multiple breath washout (MBW) was performed in seated and supine postures in 25 healthy children and 21 children with CF. Children with CF also underwent a chest CT scan. Functional residual capacity (FRC), lung clearance index (LCI) and moment ratios were calculated from the MBW test. CT scans were evaluated for CF-related structural lung disease. Results FRC was lower in the supine than in the seated posture, whereas LCI was higher in the supine than in the seated posture. In children with CF, associations between LCI and the extent of structural lung disease were stronger when performed in the supine posture. Conclusions Body posture influences lung volumes and ventilation distribution in both healthy children and children with CF. MBW testing in the supine posture strengthened associations with structural lung damage.</description><subject>Adolescent</subject><subject>Biomechanical Phenomena - physiology</subject><subject>Child</subject><subject>Computed tomography</subject><subject>Cystic fibrosis</subject><subject>Cystic Fibrosis - diagnosis</subject><subject>Cystic Fibrosis - physiopathology</subject><subject>Female</subject><subject>Functional Residual Capacity - physiology</subject><subject>Humans</subject><subject>Lung - physiopathology</subject><subject>Lung clearance index</subject><subject>Male</subject><subject>Mucociliary Clearance - physiology</subject><subject>Multiple breath washout</subject><subject>Posture</subject><subject>Posture - physiology</subject><subject>Pulmonary Ventilation - physiology</subject><subject>Pulmonary/Respiratory</subject><subject>Respiratory Function Tests - methods</subject><subject>Tomography, X-Ray Computed - methods</subject><subject>Ventilation distribution</subject><issn>1569-1993</issn><issn>1873-5010</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU9v1DAQxSMEoqXwAbggH7lk8cTrJBYSEqraglSJQ-FsOZMxnZB1Fjtptd--3t3CoYdKI_nPvPdk_6Yo3oNcgYT607Aa0K8qCc1KQi71ojiFtlGlliBf5r2uTQnGqJPiTUqDzELZtK-Lk6qFtpUAp0W68J5wFpMX2ynNSyQxBTEu4be4ozDz6GbOFz2nOXK3HA4u9MKlNCEfmknc83wrsmDBQwAHgbc89pHCsYW7NDMKz12cEqe3xSvvxkTvHtez4tflxc_zb-X1j6vv51-vS1xrmEsyBrXqDILq9NqYmpzumla5dQeuqyqFTuseZNt65XpDvQZSBg0qLX3deHVWfDzmbuP0d6E02w0npHF0gaYlWWjrRitTgcxSOEoxvzBF8nYbeePizoK0e9Z2sJm13bO2EnKp7PnwGL90G-r_O_7BzYLPRwHlT94xRZuQKSD1HDNz20_8bPyXJ24cOTC68Q_tKA3TEkOmZ8Gmykp7sx_2ftbQKCkrWasHUWSmfQ</recordid><startdate>20171101</startdate><enddate>20171101</enddate><creator>Ramsey, Kathryn A</creator><creator>McGirr, Caroline</creator><creator>Stick, Stephen M</creator><creator>Hall, Graham L</creator><creator>Simpson, Shannon J</creator><general>Elsevier B.V</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20171101</creationdate><title>Effect of posture on lung ventilation distribution and associations with structure in children with cystic fibrosis</title><author>Ramsey, Kathryn A ; McGirr, Caroline ; Stick, Stephen M ; Hall, Graham L ; Simpson, Shannon J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c451t-e99c53b9c13b54996ea5b783a4b1ab223ca55d1088f3ad9ed51e39c9c350f67f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adolescent</topic><topic>Biomechanical Phenomena - physiology</topic><topic>Child</topic><topic>Computed tomography</topic><topic>Cystic fibrosis</topic><topic>Cystic Fibrosis - diagnosis</topic><topic>Cystic Fibrosis - physiopathology</topic><topic>Female</topic><topic>Functional Residual Capacity - physiology</topic><topic>Humans</topic><topic>Lung - physiopathology</topic><topic>Lung clearance index</topic><topic>Male</topic><topic>Mucociliary Clearance - physiology</topic><topic>Multiple breath washout</topic><topic>Posture</topic><topic>Posture - physiology</topic><topic>Pulmonary Ventilation - physiology</topic><topic>Pulmonary/Respiratory</topic><topic>Respiratory Function Tests - methods</topic><topic>Tomography, X-Ray Computed - methods</topic><topic>Ventilation distribution</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ramsey, Kathryn A</creatorcontrib><creatorcontrib>McGirr, Caroline</creatorcontrib><creatorcontrib>Stick, Stephen M</creatorcontrib><creatorcontrib>Hall, Graham L</creatorcontrib><creatorcontrib>Simpson, Shannon J</creatorcontrib><creatorcontrib>on behalf of AREST CF</creatorcontrib><creatorcontrib>AREST CF</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cystic fibrosis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ramsey, Kathryn A</au><au>McGirr, Caroline</au><au>Stick, Stephen M</au><au>Hall, Graham L</au><au>Simpson, Shannon J</au><aucorp>on behalf of AREST CF</aucorp><aucorp>AREST CF</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of posture on lung ventilation distribution and associations with structure in children with cystic fibrosis</atitle><jtitle>Journal of cystic fibrosis</jtitle><addtitle>J Cyst Fibros</addtitle><date>2017-11-01</date><risdate>2017</risdate><volume>16</volume><issue>6</issue><spage>713</spage><epage>718</epage><pages>713-718</pages><issn>1569-1993</issn><eissn>1873-5010</eissn><abstract>Abstract Background We assessed the effect of posture on ventilation distribution and the impact on associations with structural lung disease. Methods Multiple breath washout (MBW) was performed in seated and supine postures in 25 healthy children and 21 children with CF. Children with CF also underwent a chest CT scan. Functional residual capacity (FRC), lung clearance index (LCI) and moment ratios were calculated from the MBW test. CT scans were evaluated for CF-related structural lung disease. Results FRC was lower in the supine than in the seated posture, whereas LCI was higher in the supine than in the seated posture. In children with CF, associations between LCI and the extent of structural lung disease were stronger when performed in the supine posture. Conclusions Body posture influences lung volumes and ventilation distribution in both healthy children and children with CF. MBW testing in the supine posture strengthened associations with structural lung damage.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>28188011</pmid><doi>10.1016/j.jcf.2017.01.013</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adolescent Biomechanical Phenomena - physiology Child Computed tomography Cystic fibrosis Cystic Fibrosis - diagnosis Cystic Fibrosis - physiopathology Female Functional Residual Capacity - physiology Humans Lung - physiopathology Lung clearance index Male Mucociliary Clearance - physiology Multiple breath washout Posture Posture - physiology Pulmonary Ventilation - physiology Pulmonary/Respiratory Respiratory Function Tests - methods Tomography, X-Ray Computed - methods Ventilation distribution |
| title | Effect of posture on lung ventilation distribution and associations with structure in children with cystic fibrosis |
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