Role of systemic injection of rabies immunoglobulin in rabies vaccination
To determine the role of systemic injection of rabies immunoglobulin (RIG) in rabies vaccination, we analyzed the level of antibody against rabies virus in the serum of mice that received various doses of RIG combined with rabies vaccine. Our results indicate that systemic injection of RIG does not...
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| Veröffentlicht in: | Archives of virology 2017-06, Vol.162 (6), p.1701-1703 |
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| container_title | Archives of virology |
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| creator | Wu, Weichen Liu, Shuqing Yu, Pengcheng Tao, Xiaoyan Lu, Xuexin Yan, Jianghong Wang, Qian Zhang, Zongshen Zhu, Wuyang |
| description | To determine the role of systemic injection of rabies immunoglobulin (RIG) in rabies vaccination, we analyzed the level of antibody against rabies virus in the serum of mice that received various doses of RIG combined with rabies vaccine. Our results indicate that systemic injection of RIG does not contribute detectably to passive or adaptive immunization, suggesting that the main function of RIG in individuals with category III exposure is to neutralize rabies virus via immediate local infiltration of the wound. |
| doi_str_mv | 10.1007/s00705-017-3263-y |
| format | Article |
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Our results indicate that systemic injection of RIG does not contribute detectably to passive or adaptive immunization, suggesting that the main function of RIG in individuals with category III exposure is to neutralize rabies virus via immediate local infiltration of the wound.</description><identifier>ISSN: 0304-8608</identifier><identifier>EISSN: 1432-8798</identifier><identifier>DOI: 10.1007/s00705-017-3263-y</identifier><identifier>PMID: 28188373</identifier><language>eng</language><publisher>Vienna: Springer Vienna</publisher><subject>Adaptive Immunity ; Animal bites ; Animals ; Antibodies, Viral - administration & dosage ; Antibodies, Viral - immunology ; Bats ; Biomedical and Life Sciences ; Biomedicine ; Brief Report ; Combined vaccines ; Female ; Humans ; Immunization ; Immunization, Passive ; Immunoglobulin G - administration & dosage ; Immunoglobulin G - immunology ; Immunoglobulins ; Infectious Diseases ; Injection ; Lyssavirus ; Male ; Medical Microbiology ; Mice ; Mice, Inbred BALB C ; Rabies ; Rabies - drug therapy ; Rabies - immunology ; Rabies - virology ; Rabies Vaccines - administration & dosage ; Rabies Vaccines - immunology ; Rabies virus - immunology ; Rabies virus - physiology ; Vaccination ; Virology ; Wounds</subject><ispartof>Archives of virology, 2017-06, Vol.162 (6), p.1701-1703</ispartof><rights>Springer-Verlag Wien 2017</rights><rights>Archives of Virology is a copyright of Springer, 2017.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-3d6086d4b354aa5a3b491911788a8f3a1c29567a2a3c0a7236e139b32584aa6f3</citedby><cites>FETCH-LOGICAL-c372t-3d6086d4b354aa5a3b491911788a8f3a1c29567a2a3c0a7236e139b32584aa6f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00705-017-3263-y$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00705-017-3263-y$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28188373$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wu, Weichen</creatorcontrib><creatorcontrib>Liu, Shuqing</creatorcontrib><creatorcontrib>Yu, Pengcheng</creatorcontrib><creatorcontrib>Tao, Xiaoyan</creatorcontrib><creatorcontrib>Lu, Xuexin</creatorcontrib><creatorcontrib>Yan, Jianghong</creatorcontrib><creatorcontrib>Wang, Qian</creatorcontrib><creatorcontrib>Zhang, Zongshen</creatorcontrib><creatorcontrib>Zhu, Wuyang</creatorcontrib><title>Role of systemic injection of rabies immunoglobulin in rabies vaccination</title><title>Archives of virology</title><addtitle>Arch Virol</addtitle><addtitle>Arch Virol</addtitle><description>To determine the role of systemic injection of rabies immunoglobulin (RIG) in rabies vaccination, we analyzed the level of antibody against rabies virus in the serum of mice that received various doses of RIG combined with rabies vaccine. Our results indicate that systemic injection of RIG does not contribute detectably to passive or adaptive immunization, suggesting that the main function of RIG in individuals with category III exposure is to neutralize rabies virus via immediate local infiltration of the wound.</description><subject>Adaptive Immunity</subject><subject>Animal bites</subject><subject>Animals</subject><subject>Antibodies, Viral - administration & dosage</subject><subject>Antibodies, Viral - immunology</subject><subject>Bats</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Brief Report</subject><subject>Combined vaccines</subject><subject>Female</subject><subject>Humans</subject><subject>Immunization</subject><subject>Immunization, Passive</subject><subject>Immunoglobulin G - administration & dosage</subject><subject>Immunoglobulin G - immunology</subject><subject>Immunoglobulins</subject><subject>Infectious Diseases</subject><subject>Injection</subject><subject>Lyssavirus</subject><subject>Male</subject><subject>Medical Microbiology</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Rabies</subject><subject>Rabies - drug therapy</subject><subject>Rabies - immunology</subject><subject>Rabies - virology</subject><subject>Rabies Vaccines - administration & dosage</subject><subject>Rabies Vaccines - immunology</subject><subject>Rabies virus - immunology</subject><subject>Rabies virus - physiology</subject><subject>Vaccination</subject><subject>Virology</subject><subject>Wounds</subject><issn>0304-8608</issn><issn>1432-8798</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kE1LxDAQhoMo7rr6A7xIwYuXapJpk_Qoi1-wIIieQ5pNlyxtsjat0H9vSndFBC8JzDzzzvAgdEnwLcGY34X44DzFhKdAGaTDEZqTDGgqeCGO0RwDzlLBsJihsxC2GMcC5KdoRgURAjjM0cubr03iqyQMoTON1Yl1W6M7691YbVVpTUhs0_TOb2pf9rV1ETk0vpTW1qkRP0cnlaqDudj_C_Tx-PC-fE5Xr08vy_tVqoHTLoV1vIetsxLyTKlcQZkVpCCEC6FEBYpoWuSMK6pAY8UpMEOgKIHmIvKsggW6mXJ3rf_sTehkY4M2da2c8X2QRDCeg4CMR_T6D7r1fevidZEqCs4pKyBSZKJ060NoTSV3rW1UO0iC5ehZTp5l9CxHz3KIM1f75L5szPpn4iA2AnQCQmy5jWl_rf439RuDrod9</recordid><startdate>20170601</startdate><enddate>20170601</enddate><creator>Wu, Weichen</creator><creator>Liu, Shuqing</creator><creator>Yu, Pengcheng</creator><creator>Tao, Xiaoyan</creator><creator>Lu, Xuexin</creator><creator>Yan, Jianghong</creator><creator>Wang, Qian</creator><creator>Zhang, Zongshen</creator><creator>Zhu, Wuyang</creator><general>Springer Vienna</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20170601</creationdate><title>Role of systemic injection of rabies immunoglobulin in rabies vaccination</title><author>Wu, Weichen ; Liu, Shuqing ; Yu, Pengcheng ; Tao, Xiaoyan ; Lu, Xuexin ; Yan, Jianghong ; Wang, Qian ; Zhang, Zongshen ; Zhu, Wuyang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-3d6086d4b354aa5a3b491911788a8f3a1c29567a2a3c0a7236e139b32584aa6f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adaptive Immunity</topic><topic>Animal bites</topic><topic>Animals</topic><topic>Antibodies, Viral - administration & dosage</topic><topic>Antibodies, Viral - immunology</topic><topic>Bats</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Brief Report</topic><topic>Combined vaccines</topic><topic>Female</topic><topic>Humans</topic><topic>Immunization</topic><topic>Immunization, Passive</topic><topic>Immunoglobulin G - administration & dosage</topic><topic>Immunoglobulin G - immunology</topic><topic>Immunoglobulins</topic><topic>Infectious Diseases</topic><topic>Injection</topic><topic>Lyssavirus</topic><topic>Male</topic><topic>Medical Microbiology</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Rabies</topic><topic>Rabies - drug therapy</topic><topic>Rabies - immunology</topic><topic>Rabies - virology</topic><topic>Rabies Vaccines - administration & dosage</topic><topic>Rabies Vaccines - immunology</topic><topic>Rabies virus - immunology</topic><topic>Rabies virus - physiology</topic><topic>Vaccination</topic><topic>Virology</topic><topic>Wounds</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wu, Weichen</creatorcontrib><creatorcontrib>Liu, Shuqing</creatorcontrib><creatorcontrib>Yu, Pengcheng</creatorcontrib><creatorcontrib>Tao, Xiaoyan</creatorcontrib><creatorcontrib>Lu, Xuexin</creatorcontrib><creatorcontrib>Yan, Jianghong</creatorcontrib><creatorcontrib>Wang, Qian</creatorcontrib><creatorcontrib>Zhang, Zongshen</creatorcontrib><creatorcontrib>Zhu, Wuyang</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Archives of virology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wu, Weichen</au><au>Liu, Shuqing</au><au>Yu, Pengcheng</au><au>Tao, Xiaoyan</au><au>Lu, Xuexin</au><au>Yan, Jianghong</au><au>Wang, Qian</au><au>Zhang, Zongshen</au><au>Zhu, Wuyang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of systemic injection of rabies immunoglobulin in rabies vaccination</atitle><jtitle>Archives of virology</jtitle><stitle>Arch Virol</stitle><addtitle>Arch Virol</addtitle><date>2017-06-01</date><risdate>2017</risdate><volume>162</volume><issue>6</issue><spage>1701</spage><epage>1703</epage><pages>1701-1703</pages><issn>0304-8608</issn><eissn>1432-8798</eissn><abstract>To determine the role of systemic injection of rabies immunoglobulin (RIG) in rabies vaccination, we analyzed the level of antibody against rabies virus in the serum of mice that received various doses of RIG combined with rabies vaccine. Our results indicate that systemic injection of RIG does not contribute detectably to passive or adaptive immunization, suggesting that the main function of RIG in individuals with category III exposure is to neutralize rabies virus via immediate local infiltration of the wound.</abstract><cop>Vienna</cop><pub>Springer Vienna</pub><pmid>28188373</pmid><doi>10.1007/s00705-017-3263-y</doi><tpages>3</tpages></addata></record> |
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| subjects | Adaptive Immunity Animal bites Animals Antibodies, Viral - administration & dosage Antibodies, Viral - immunology Bats Biomedical and Life Sciences Biomedicine Brief Report Combined vaccines Female Humans Immunization Immunization, Passive Immunoglobulin G - administration & dosage Immunoglobulin G - immunology Immunoglobulins Infectious Diseases Injection Lyssavirus Male Medical Microbiology Mice Mice, Inbred BALB C Rabies Rabies - drug therapy Rabies - immunology Rabies - virology Rabies Vaccines - administration & dosage Rabies Vaccines - immunology Rabies virus - immunology Rabies virus - physiology Vaccination Virology Wounds |
| title | Role of systemic injection of rabies immunoglobulin in rabies vaccination |
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