Dual Roles of IL-4 in Lung Injury and Fibrosis

Increased lung IL-4 expression in pulmonary fibrosis suggests a potential pathogenetic role for this cytokine. To dissect this role, bleomycin-induced pulmonary inflammation and fibrosis were analyzed and compared in wild type (IL-4(+/+)) vs IL-4-deficient (IL-4(-/-)) mice. Lethal pulmonary injury a...

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Veröffentlicht in:	The Journal of immunology (1950) 2003-02, Vol.170 (4), p.2083-2092
Hauptverfasser:	Huaux, Francois, Liu, Tianju, McGarry, Bridget, Ullenbruch, Matt, Phan, Sem H
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Animals Antibodies, Monoclonal - therapeutic use Bleomycin - administration & dosage CD3 Complex - immunology Cell Differentiation - drug effects Cell Differentiation - immunology Cell Division - drug effects Cell Division - immunology Cells, Cultured Coculture Techniques Female Fibroblasts - immunology Fibroblasts - pathology Inflammation - chemically induced Inflammation - genetics Inflammation - immunology Interleukin-4 - deficiency Interleukin-4 - genetics Interleukin-4 - physiology Intubation, Intratracheal Lung - drug effects Lung - immunology Lung - pathology Mice Mice, Inbred C57BL Mice, Inbred CBA Mice, Knockout Pulmonary Fibrosis - chemically induced Pulmonary Fibrosis - genetics Pulmonary Fibrosis - immunology Pulmonary Fibrosis - mortality T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - metabolism T-Lymphocyte Subsets - pathology
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