Single-dose topical exposure to the pyrethroid insecticide, permethrin in C57BL/6N mice: effects on thymus and spleen

Immunomodulatory effects of single topical exposure to permethrin were evaluated in 5-week-old female C57BL/6N mice. Mice exposed to 5–25 μl permethrin (equivalent to 220–1100 mg/kg body weight) on shaved interscapular skin were evaluated for altered body weight; splenic and thymic organ weight and...

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Veröffentlicht in:	Food and chemical toxicology 2002-12, Vol.40 (12), p.1863-1873
Hauptverfasser:	Prater, M.R., Gogal Jr, R.M., Blaylock, B.L., Longstreth, J., Holladay, S.D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Topical Animals Antibody Formation - drug effects Apoptosis Apoptosis - drug effects B-Lymphocytes - drug effects Biological and medical sciences C57BL/6N mouse Cell Division - drug effects Chemiluminescence Female Flow Cytometry Hemolytic Plaque Technique Immunomodulation Insecticides - administration & dosage Insecticides - toxicity Luminescent Measurements Lymphocyte phenotypes Medical sciences Mice Mice, Inbred C57BL Organ Size - drug effects Permethrin Permethrin - administration & dosage Permethrin - toxicity Pesticide Pesticides, fertilizers and other agrochemicals toxicology Plaque forming cell assay Proliferation Spleen - drug effects Spleen - immunology Spleen - pathology Splenocyte T-Lymphocytes - drug effects Thymocyte Thymus Gland - drug effects Thymus Gland - immunology Thymus Gland - pathology Toxicology
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