Effect of ARA9 on dioxin receptor mediated transcription

The dioxin (Aryl hydrocarbon) receptor (DR) is a unique bHLH transcription factor which is activated by binding of planar aromatic hydrocarbons typified by dioxin (TCDD). The active receptor is key to metabolism of aryl hydrocarbon xenobiotics by being a potent inducer of CYP1A1 gene activity. Chlor...

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Veröffentlicht in:	Toxicology (Amsterdam) 2002-12, Vol.181, p.143-146
Hauptverfasser:	Lees, M.J, Whitelaw, M.L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antisense Elements (Genetics) - genetics Biological and medical sciences Dioxins Environmental pollutants toxicology General aspects Helix-Loop-Helix Motifs - genetics Humans Intracellular Signaling Peptides and Proteins Medical sciences Nuclear Localization Signals - genetics Proteins - toxicity Receptors Receptors, Aryl Hydrocarbon - drug effects Response Elements Signal Transduction - genetics TCDD Toxicology Transcription Transcription, Genetic - drug effects
Online-Zugang:	Volltext
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