Impact of deep brain stimulation of the ventral anterior limb of the internal capsule on cognition in depression
Preliminary studies report no negative and a possible positive impact of deep brain stimulation (DBS) on cognition of patients with treatment-resistant depression (TRD). However, these studies neither controlled for practice effects nor compared active with sham stimulation. To address these limitat...
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| Veröffentlicht in: | Psychological medicine 2017-07, Vol.47 (9), p.1647-1658 |
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| creator | Bergfeld, I. O. Mantione, M. Hoogendoorn, M. L. C. Ruhé, H. G. Horst, F. Notten, P. van Laarhoven, J. van den Munckhof, P. Beute, G. Schuurman, P. R. Denys, D. |
| description | Preliminary studies report no negative and a possible positive impact of deep brain stimulation (DBS) on cognition of patients with treatment-resistant depression (TRD). However, these studies neither controlled for practice effects nor compared active with sham stimulation.
To address these limitations, we compared 25 TRD patients, who underwent DBS of the ventral anterior limb of the internal capsule (vALIC), with 21 healthy controls (HCs) matched on gender, age and education level. Both groups did subtests of the Cambridge Neuropsychological Test Automated Battery assessing verbal and visuospatial memory, attention, cognitive flexibility, psychomotor functioning, planning and object naming. TRD patients were tested 3 weeks prior to DBS surgery (baseline), 3 weeks following surgery (T1) and following 52 weeks of DBS optimization (T2). HCs were tested at baseline, 6 weeks following baseline (T1) and 20-24 weeks following baseline (T2). Subsequently, TRD patients entered a randomized, double-blind crossover phase, in which they were tested in an active and a sham stimulation phase.
TRD patients did not improve on a test of immediate verbal recognition from baseline to T1, whereas HCs did (group x time: p = 0.001). Both TRD patients and HCs improved over sessions on tests measuring delayed verbal recall, visuospatial memory, planning and object naming (all p < 0.01). Active and sham stimulation did not have an impact on any of the tests differentially.
vALIC DBS neither has a lasting positive nor negative impact on cognition in TRD patients. DBS surgery might have a temporary negative effect on verbal memory. |
| doi_str_mv | 10.1017/S0033291717000113 |
| format | Article |
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To address these limitations, we compared 25 TRD patients, who underwent DBS of the ventral anterior limb of the internal capsule (vALIC), with 21 healthy controls (HCs) matched on gender, age and education level. Both groups did subtests of the Cambridge Neuropsychological Test Automated Battery assessing verbal and visuospatial memory, attention, cognitive flexibility, psychomotor functioning, planning and object naming. TRD patients were tested 3 weeks prior to DBS surgery (baseline), 3 weeks following surgery (T1) and following 52 weeks of DBS optimization (T2). HCs were tested at baseline, 6 weeks following baseline (T1) and 20-24 weeks following baseline (T2). Subsequently, TRD patients entered a randomized, double-blind crossover phase, in which they were tested in an active and a sham stimulation phase.
TRD patients did not improve on a test of immediate verbal recognition from baseline to T1, whereas HCs did (group x time: p = 0.001). Both TRD patients and HCs improved over sessions on tests measuring delayed verbal recall, visuospatial memory, planning and object naming (all p < 0.01). Active and sham stimulation did not have an impact on any of the tests differentially.
vALIC DBS neither has a lasting positive nor negative impact on cognition in TRD patients. DBS surgery might have a temporary negative effect on verbal memory.</description><identifier>ISSN: 0033-2917</identifier><identifier>EISSN: 1469-8978</identifier><identifier>DOI: 10.1017/S0033291717000113</identifier><identifier>PMID: 28179035</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>Adult ; Antidepressants ; Attention ; Brain ; Brain research ; Cognition ; Cognition & reasoning ; Cognitive ability ; Cognitive Dysfunction - etiology ; Cognitive Dysfunction - therapy ; Cognitive flexibility ; Deep brain stimulation ; Deep Brain Stimulation - methods ; Delayed ; Depressive Disorder, Treatment-Resistant - complications ; Depressive Disorder, Treatment-Resistant - therapy ; Double-Blind Method ; Double-blind studies ; Education ; Electroconvulsive therapy ; Female ; Humans ; Internal Capsule - physiopathology ; Male ; Memory Disorders - etiology ; Memory Disorders - therapy ; Mental depression ; Middle Aged ; Naming ; Neuropsychological assessment ; Neurosciences ; Neurosurgery ; Optimization ; Original Articles ; Patients ; Psychiatrists ; Psychiatry ; Psychomotor efficiency ; Refractory depression ; Spatial memory ; Stimulation ; Surgery ; Treatment Outcome ; Verbal memory ; Visual memory</subject><ispartof>Psychological medicine, 2017-07, Vol.47 (9), p.1647-1658</ispartof><rights>Copyright © Cambridge University Press 2017</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c373t-51904569ed1994ed6cac31d0a76b2fe8812e1ce4676212e9b2332bf127dad7713</citedby><cites>FETCH-LOGICAL-c373t-51904569ed1994ed6cac31d0a76b2fe8812e1ce4676212e9b2332bf127dad7713</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.cambridge.org/core/product/identifier/S0033291717000113/type/journal_article$$EHTML$$P50$$Gcambridge$$H</linktohtml><link.rule.ids>164,314,780,784,12846,27924,27925,30999,55628</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28179035$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bergfeld, I. O.</creatorcontrib><creatorcontrib>Mantione, M.</creatorcontrib><creatorcontrib>Hoogendoorn, M. L. C.</creatorcontrib><creatorcontrib>Ruhé, H. G.</creatorcontrib><creatorcontrib>Horst, F.</creatorcontrib><creatorcontrib>Notten, P.</creatorcontrib><creatorcontrib>van Laarhoven, J.</creatorcontrib><creatorcontrib>van den Munckhof, P.</creatorcontrib><creatorcontrib>Beute, G.</creatorcontrib><creatorcontrib>Schuurman, P. R.</creatorcontrib><creatorcontrib>Denys, D.</creatorcontrib><title>Impact of deep brain stimulation of the ventral anterior limb of the internal capsule on cognition in depression</title><title>Psychological medicine</title><addtitle>Psychol. Med</addtitle><description>Preliminary studies report no negative and a possible positive impact of deep brain stimulation (DBS) on cognition of patients with treatment-resistant depression (TRD). However, these studies neither controlled for practice effects nor compared active with sham stimulation.
To address these limitations, we compared 25 TRD patients, who underwent DBS of the ventral anterior limb of the internal capsule (vALIC), with 21 healthy controls (HCs) matched on gender, age and education level. Both groups did subtests of the Cambridge Neuropsychological Test Automated Battery assessing verbal and visuospatial memory, attention, cognitive flexibility, psychomotor functioning, planning and object naming. TRD patients were tested 3 weeks prior to DBS surgery (baseline), 3 weeks following surgery (T1) and following 52 weeks of DBS optimization (T2). HCs were tested at baseline, 6 weeks following baseline (T1) and 20-24 weeks following baseline (T2). Subsequently, TRD patients entered a randomized, double-blind crossover phase, in which they were tested in an active and a sham stimulation phase.
TRD patients did not improve on a test of immediate verbal recognition from baseline to T1, whereas HCs did (group x time: p = 0.001). Both TRD patients and HCs improved over sessions on tests measuring delayed verbal recall, visuospatial memory, planning and object naming (all p < 0.01). Active and sham stimulation did not have an impact on any of the tests differentially.
vALIC DBS neither has a lasting positive nor negative impact on cognition in TRD patients. DBS surgery might have a temporary negative effect on verbal memory.</description><subject>Adult</subject><subject>Antidepressants</subject><subject>Attention</subject><subject>Brain</subject><subject>Brain research</subject><subject>Cognition</subject><subject>Cognition & reasoning</subject><subject>Cognitive ability</subject><subject>Cognitive Dysfunction - etiology</subject><subject>Cognitive Dysfunction - therapy</subject><subject>Cognitive flexibility</subject><subject>Deep brain stimulation</subject><subject>Deep Brain Stimulation - methods</subject><subject>Delayed</subject><subject>Depressive Disorder, Treatment-Resistant - complications</subject><subject>Depressive Disorder, Treatment-Resistant - therapy</subject><subject>Double-Blind Method</subject><subject>Double-blind studies</subject><subject>Education</subject><subject>Electroconvulsive therapy</subject><subject>Female</subject><subject>Humans</subject><subject>Internal Capsule - physiopathology</subject><subject>Male</subject><subject>Memory Disorders - etiology</subject><subject>Memory Disorders - therapy</subject><subject>Mental depression</subject><subject>Middle Aged</subject><subject>Naming</subject><subject>Neuropsychological assessment</subject><subject>Neurosciences</subject><subject>Neurosurgery</subject><subject>Optimization</subject><subject>Original Articles</subject><subject>Patients</subject><subject>Psychiatrists</subject><subject>Psychiatry</subject><subject>Psychomotor efficiency</subject><subject>Refractory depression</subject><subject>Spatial memory</subject><subject>Stimulation</subject><subject>Surgery</subject><subject>Treatment Outcome</subject><subject>Verbal memory</subject><subject>Visual memory</subject><issn>0033-2917</issn><issn>1469-8978</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>7QJ</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp1kctOwzAQRS0EoqXwAWxQJDZsAp44teMlQjwqVWIBrCPHnhRXeWEnSPw9Dm0RArHy4557x54h5BToJVAQV0-UMpZIECAopQBsj0wh5TLOpMj2yXSU41GfkCPv1wFhkCaHZJJkICRl8ynpFnWndB-1ZWQQu6hwyjaR7209VKq3bTMq_StG79j0TlWRanp0tnVRZetiJ9rxsgmqVp0fKoyCT7erxn4lhECDnUPvw-mYHJSq8niyXWfk5e72-eYhXj7eL26ul7FmgvXxHCRN51yiASlTNFwrzcBQJXiRlJhlkCBoTLngSdjKIgmdKEpIhFFGCGAzcrHJ7Vz7NqDv89p6jVWlGmwHn0PGOZfBxAJ6_gtdt8P4nUCFVwiehR4GCjaUdq33Dsu8c7ZW7iMHmo_jyP-MI3jOtslDUaP5duz6HwC2DVV14axZ4Y_a_8Z-AsC8lAk</recordid><startdate>201707</startdate><enddate>201707</enddate><creator>Bergfeld, I. 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O. ; Mantione, M. ; Hoogendoorn, M. L. C. ; Ruhé, H. G. ; Horst, F. ; Notten, P. ; van Laarhoven, J. ; van den Munckhof, P. ; Beute, G. ; Schuurman, P. 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O.</au><au>Mantione, M.</au><au>Hoogendoorn, M. L. C.</au><au>Ruhé, H. G.</au><au>Horst, F.</au><au>Notten, P.</au><au>van Laarhoven, J.</au><au>van den Munckhof, P.</au><au>Beute, G.</au><au>Schuurman, P. R.</au><au>Denys, D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of deep brain stimulation of the ventral anterior limb of the internal capsule on cognition in depression</atitle><jtitle>Psychological medicine</jtitle><addtitle>Psychol. Med</addtitle><date>2017-07</date><risdate>2017</risdate><volume>47</volume><issue>9</issue><spage>1647</spage><epage>1658</epage><pages>1647-1658</pages><issn>0033-2917</issn><eissn>1469-8978</eissn><abstract>Preliminary studies report no negative and a possible positive impact of deep brain stimulation (DBS) on cognition of patients with treatment-resistant depression (TRD). However, these studies neither controlled for practice effects nor compared active with sham stimulation.
To address these limitations, we compared 25 TRD patients, who underwent DBS of the ventral anterior limb of the internal capsule (vALIC), with 21 healthy controls (HCs) matched on gender, age and education level. Both groups did subtests of the Cambridge Neuropsychological Test Automated Battery assessing verbal and visuospatial memory, attention, cognitive flexibility, psychomotor functioning, planning and object naming. TRD patients were tested 3 weeks prior to DBS surgery (baseline), 3 weeks following surgery (T1) and following 52 weeks of DBS optimization (T2). HCs were tested at baseline, 6 weeks following baseline (T1) and 20-24 weeks following baseline (T2). Subsequently, TRD patients entered a randomized, double-blind crossover phase, in which they were tested in an active and a sham stimulation phase.
TRD patients did not improve on a test of immediate verbal recognition from baseline to T1, whereas HCs did (group x time: p = 0.001). Both TRD patients and HCs improved over sessions on tests measuring delayed verbal recall, visuospatial memory, planning and object naming (all p < 0.01). Active and sham stimulation did not have an impact on any of the tests differentially.
vALIC DBS neither has a lasting positive nor negative impact on cognition in TRD patients. DBS surgery might have a temporary negative effect on verbal memory.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>28179035</pmid><doi>10.1017/S0033291717000113</doi><tpages>12</tpages></addata></record> |
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| ispartof | Psychological medicine, 2017-07, Vol.47 (9), p.1647-1658 |
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| source | MEDLINE; Applied Social Sciences Index & Abstracts (ASSIA); Cambridge University Press Journals Complete |
| subjects | Adult Antidepressants Attention Brain Brain research Cognition Cognition & reasoning Cognitive ability Cognitive Dysfunction - etiology Cognitive Dysfunction - therapy Cognitive flexibility Deep brain stimulation Deep Brain Stimulation - methods Delayed Depressive Disorder, Treatment-Resistant - complications Depressive Disorder, Treatment-Resistant - therapy Double-Blind Method Double-blind studies Education Electroconvulsive therapy Female Humans Internal Capsule - physiopathology Male Memory Disorders - etiology Memory Disorders - therapy Mental depression Middle Aged Naming Neuropsychological assessment Neurosciences Neurosurgery Optimization Original Articles Patients Psychiatrists Psychiatry Psychomotor efficiency Refractory depression Spatial memory Stimulation Surgery Treatment Outcome Verbal memory Visual memory |
| title | Impact of deep brain stimulation of the ventral anterior limb of the internal capsule on cognition in depression |
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