Administration of anabolic steroid during adolescence induces long-term cardiac hypertrophy and increases susceptibility to ischemia/reperfusion injury in adult Wistar rats

•Chronic administration of AAS during adolescence promoted persistent cardiac hypertrophy in adulthood.•Cardiac hypertrophy was characterized by up-regulation in the βMHC expression, compatible with pathologic hypertrophy.•Susceptibility to myocardial IR injury in adult life was significantly increa...

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Veröffentlicht in:	The Journal of steroid biochemistry and molecular biology 2017-07, Vol.171, p.34-42
Hauptverfasser:	Seara, Fernando de Azevedo Cruz, Barbosa, Raiana Andrade Quintanilha, de Oliveira, Dahienne Ferreira, Gran da Silva, Diorney Luiz Souza, Carvalho, Adriana Bastos, Freitas Ferreira, Andrea Claudia, Matheus Nascimento, José Hamilton, Olivares, Emerson Lopes
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescence Adolescents Aging Anabolic Agents - administration & dosage Anabolic Agents - toxicity Anabolic steroids Androgens Androgens - administration & dosage Androgens - toxicity Angiotensin AT1 receptors Angiotensin II Animals Antioxidants Blood pressure Brain natriuretic peptide Ca2+-transporting ATPase Calcium (reticular) Cardiac muscle Cardiomegaly - chemically induced Cardiomegaly - physiopathology Catalase Catalase - antagonists & inhibitors Catalase - genetics Catalase - metabolism Coronary Vessels - drug effects Coronary Vessels - physiopathology Down-regulation Dysautonomia Enzymes Gene expression Gene Expression Regulation, Developmental - drug effects Heart Heart - drug effects Heart - physiopathology Heart attacks Heart diseases Hypertrophy Injections, Intramuscular IR injury Ischemia Male Mechanical properties Myocardial infarction Myocardial Ischemia - chemically induced Myocardial Ischemia - pathology Myocardial Ischemia - physiopathology Myocardial Reperfusion Injury - chemically induced Myocardial Reperfusion Injury - pathology Myocardial Reperfusion Injury - physiopathology Myocardium - enzymology Myocardium - metabolism Myocardium - pathology Myosin Heavy Chains - chemistry Myosin Heavy Chains - genetics Myosin Heavy Chains - metabolism NAD(P)H oxidase Polymerase chain reaction Potassium channels (inwardly-rectifying) Random Allocation Rats, Wistar Reactive oxygen species Reactive Oxygen Species - metabolism Reperfusion Ryanodine receptors Steroids Testosterone Testosterone Propionate - administration & dosage Testosterone Propionate - toxicity Time Factors
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