Inhibition of cytochrome P450 enzymes by saturated and unsaturated fatty acids in human liver microsomes, characterization of enzyme kinetics in the presence of bovine serum albumin (0.1 and 1.0% w/v) and in vitro – in vivo extrapolation of hepatic clearance

The objective of the study was to determine the effect of fatty acids on CYP enzymes and the effect of BSA on intrinsic clearance of probe substrates. The inhibitory effect of thirteen fatty acids including saturated, mono-unsaturated and polyunsaturated fatty acids on CYP enzymes, kinetic parameter...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	European journal of pharmaceutical sciences 2017-04, Vol.101, p.80-89
Hauptverfasser:	Palacharla, Raghava Choudary, Uthukam, Venkatesham, Manoharan, Arunkumar, Ponnamaneni, Ranjith Kumar, Padala, Nagasurya Prakash, Boggavarapu, Rajesh Kumar, Bhyrapuneni, Gopinadh, Ajjala, Devender Reddy, Nirogi, Ramakrishna
Format:	Artikel
Sprache:	eng
Schlagworte:	Bovine serum albumin (BSA) CYP450 enzymes Cytochrome P-450 Enzyme Inhibitors - pharmacology Cytochrome P-450 Enzyme System - metabolism Enzyme inhibition Fatty acids Fatty Acids - pharmacology Fatty Acids, Unsaturated - pharmacology Hepatic clearance Humans In vitro – In vivo extrapolation (IVIVE) Intrinsic clearance Kinetics Liver - drug effects Liver - metabolism Michaelis-Menten kinetics Microsomes, Liver - drug effects Microsomes, Liver - metabolism Serum Albumin, Bovine - metabolism Well-stirred model
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!