Urothelial Carcinoma With Squamous Differentiation Is Associated With High Tumor Stage and Pelvic Lymph-Node Metastasis
Squamous differentiation occurs in up to 20% of urothelial carcinoma cases and is thought to be an unfavorable prognostic factor. Data from urothelial carcinoma in patients treated with cystectomy from 2002 to 2014 at Roswell Park Cancer Institute were retrospectively reviewed. A 2-tier system was a...
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| Veröffentlicht in: | Cancer control 2017-01, Vol.24 (1), p.78-82 |
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| creator | Liu, Yunguang Bui, Marilyn M Xu, Bo |
| description | Squamous differentiation occurs in up to 20% of urothelial carcinoma cases and is thought to be an unfavorable prognostic factor.
Data from urothelial carcinoma in patients treated with cystectomy from 2002 to 2014 at Roswell Park Cancer Institute were retrospectively reviewed. A 2-tier system was adopted for stage analysis. T1 and T2 disease were grouped in organ-confined and low-stage categories, whereas T3 and T4 disease were grouped in high-stage categories. The extent of squamous differentiation was semi-quantified as focal (≤20%) or extensive (> 20%).
Squamous differentiation occurred in 19.3% (47 of 244) of cases. Urothelial carcinoma with squamous differentiation presented with a significantly higher rate of high-stage disease compared with pure urothelial carcinoma (72.3% vs 43.1%; P < .01). The nodal metastatic rate in urothelial carcinoma with extensive squamous differentiation was significantly higher than that seen in pure urothelial carcinoma (46.2% vs 27.0%; P = .04).
Urothelial carcinoma with squamous differentiation is associated with advanced tumor stage. In addition, urothelial carcinoma with extensive squamous differentiation presented with a significantly higher rate of nodal metastasis. These findings can be the contributing factors for the unfavorable clinical outcomes seen in patients with urothelial carcinoma and squamous differentiation. |
| doi_str_mv | 10.1177/107327481702400113 |
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Data from urothelial carcinoma in patients treated with cystectomy from 2002 to 2014 at Roswell Park Cancer Institute were retrospectively reviewed. A 2-tier system was adopted for stage analysis. T1 and T2 disease were grouped in organ-confined and low-stage categories, whereas T3 and T4 disease were grouped in high-stage categories. The extent of squamous differentiation was semi-quantified as focal (≤20%) or extensive (> 20%).
Squamous differentiation occurred in 19.3% (47 of 244) of cases. Urothelial carcinoma with squamous differentiation presented with a significantly higher rate of high-stage disease compared with pure urothelial carcinoma (72.3% vs 43.1%; P < .01). The nodal metastatic rate in urothelial carcinoma with extensive squamous differentiation was significantly higher than that seen in pure urothelial carcinoma (46.2% vs 27.0%; P = .04).
Urothelial carcinoma with squamous differentiation is associated with advanced tumor stage. In addition, urothelial carcinoma with extensive squamous differentiation presented with a significantly higher rate of nodal metastasis. These findings can be the contributing factors for the unfavorable clinical outcomes seen in patients with urothelial carcinoma and squamous differentiation.</description><identifier>ISSN: 1073-2748</identifier><identifier>EISSN: 1526-2359</identifier><identifier>EISSN: 1073-2748</identifier><identifier>DOI: 10.1177/107327481702400113</identifier><identifier>PMID: 28178718</identifier><language>eng</language><publisher>United States</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Carcinoma, Squamous Cell - secondary ; Carcinoma, Squamous Cell - surgery ; Cell Differentiation ; Cystectomy ; Female ; Follow-Up Studies ; Humans ; Lymph Nodes - pathology ; Lymph Nodes - surgery ; Lymphatic Metastasis ; Male ; Middle Aged ; Neoplasm Invasiveness ; Neoplasm Staging ; Pelvic Neoplasms - secondary ; Pelvic Neoplasms - surgery ; Prognosis ; Retrospective Studies ; Urinary Bladder Neoplasms - pathology ; Urinary Bladder Neoplasms - surgery</subject><ispartof>Cancer control, 2017-01, Vol.24 (1), p.78-82</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c347t-3e3407cf30de5713e519e2c6785290f4fafa36b17d42abd816e3301ccd6f88163</citedby><cites>FETCH-LOGICAL-c347t-3e3407cf30de5713e519e2c6785290f4fafa36b17d42abd816e3301ccd6f88163</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28178718$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Yunguang</creatorcontrib><creatorcontrib>Bui, Marilyn M</creatorcontrib><creatorcontrib>Xu, Bo</creatorcontrib><title>Urothelial Carcinoma With Squamous Differentiation Is Associated With High Tumor Stage and Pelvic Lymph-Node Metastasis</title><title>Cancer control</title><addtitle>Cancer Control</addtitle><description>Squamous differentiation occurs in up to 20% of urothelial carcinoma cases and is thought to be an unfavorable prognostic factor.
Data from urothelial carcinoma in patients treated with cystectomy from 2002 to 2014 at Roswell Park Cancer Institute were retrospectively reviewed. A 2-tier system was adopted for stage analysis. T1 and T2 disease were grouped in organ-confined and low-stage categories, whereas T3 and T4 disease were grouped in high-stage categories. The extent of squamous differentiation was semi-quantified as focal (≤20%) or extensive (> 20%).
Squamous differentiation occurred in 19.3% (47 of 244) of cases. Urothelial carcinoma with squamous differentiation presented with a significantly higher rate of high-stage disease compared with pure urothelial carcinoma (72.3% vs 43.1%; P < .01). The nodal metastatic rate in urothelial carcinoma with extensive squamous differentiation was significantly higher than that seen in pure urothelial carcinoma (46.2% vs 27.0%; P = .04).
Urothelial carcinoma with squamous differentiation is associated with advanced tumor stage. In addition, urothelial carcinoma with extensive squamous differentiation presented with a significantly higher rate of nodal metastasis. These findings can be the contributing factors for the unfavorable clinical outcomes seen in patients with urothelial carcinoma and squamous differentiation.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Carcinoma, Squamous Cell - secondary</subject><subject>Carcinoma, Squamous Cell - surgery</subject><subject>Cell Differentiation</subject><subject>Cystectomy</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Lymph Nodes - pathology</subject><subject>Lymph Nodes - surgery</subject><subject>Lymphatic Metastasis</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neoplasm Invasiveness</subject><subject>Neoplasm Staging</subject><subject>Pelvic Neoplasms - secondary</subject><subject>Pelvic Neoplasms - surgery</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>Urinary Bladder Neoplasms - pathology</subject><subject>Urinary Bladder Neoplasms - surgery</subject><issn>1073-2748</issn><issn>1526-2359</issn><issn>1073-2748</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNplkEtLw0AUhQdRbK3-ARcySzfReSSZdFnqo4X6gLa4DNPJnWYkybQzidJ_75RWN8KFew9858A9CF1TckepEPeUCM5EnFFBWEwIpfwE9WnC0ojxZHga7gBEe6KHLrz_JISRmMfnqMeCJxM066PvpbNtCZWRFR5Lp0xja4k_TFvi-baTte08fjBag4OmNbI1tsFTj0feWxUkFAd2YtYlXnS1dXjeyjVg2RT4Haovo_BsV2_K6NUWgF-glT6M8ZfoTMvKw9VxD9Dy6XExnkSzt-fpeDSLFI9FG3HgMRFKc1JAIiiHhA6BqVRkCRsSHWupJU9XVBQxk6sioylwTqhSRaqzoPgA3R5yN85uO_BtXhuvoKpkA-G3nGZpmg5ZwkVA2QFVznrvQOcbZ2rpdjkl-b7w_H_hwXRzzO9WNRR_lt-G-Q_vFnuK</recordid><startdate>201701</startdate><enddate>201701</enddate><creator>Liu, Yunguang</creator><creator>Bui, Marilyn M</creator><creator>Xu, Bo</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201701</creationdate><title>Urothelial Carcinoma With Squamous Differentiation Is Associated With High Tumor Stage and Pelvic Lymph-Node Metastasis</title><author>Liu, Yunguang ; Bui, Marilyn M ; Xu, Bo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c347t-3e3407cf30de5713e519e2c6785290f4fafa36b17d42abd816e3301ccd6f88163</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Carcinoma, Squamous Cell - secondary</topic><topic>Carcinoma, Squamous Cell - surgery</topic><topic>Cell Differentiation</topic><topic>Cystectomy</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Lymph Nodes - pathology</topic><topic>Lymph Nodes - surgery</topic><topic>Lymphatic Metastasis</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neoplasm Invasiveness</topic><topic>Neoplasm Staging</topic><topic>Pelvic Neoplasms - secondary</topic><topic>Pelvic Neoplasms - surgery</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><topic>Urinary Bladder Neoplasms - pathology</topic><topic>Urinary Bladder Neoplasms - surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Yunguang</creatorcontrib><creatorcontrib>Bui, Marilyn M</creatorcontrib><creatorcontrib>Xu, Bo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer control</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Yunguang</au><au>Bui, Marilyn M</au><au>Xu, Bo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Urothelial Carcinoma With Squamous Differentiation Is Associated With High Tumor Stage and Pelvic Lymph-Node Metastasis</atitle><jtitle>Cancer control</jtitle><addtitle>Cancer Control</addtitle><date>2017-01</date><risdate>2017</risdate><volume>24</volume><issue>1</issue><spage>78</spage><epage>82</epage><pages>78-82</pages><issn>1073-2748</issn><eissn>1526-2359</eissn><eissn>1073-2748</eissn><abstract>Squamous differentiation occurs in up to 20% of urothelial carcinoma cases and is thought to be an unfavorable prognostic factor.
Data from urothelial carcinoma in patients treated with cystectomy from 2002 to 2014 at Roswell Park Cancer Institute were retrospectively reviewed. A 2-tier system was adopted for stage analysis. T1 and T2 disease were grouped in organ-confined and low-stage categories, whereas T3 and T4 disease were grouped in high-stage categories. The extent of squamous differentiation was semi-quantified as focal (≤20%) or extensive (> 20%).
Squamous differentiation occurred in 19.3% (47 of 244) of cases. Urothelial carcinoma with squamous differentiation presented with a significantly higher rate of high-stage disease compared with pure urothelial carcinoma (72.3% vs 43.1%; P < .01). The nodal metastatic rate in urothelial carcinoma with extensive squamous differentiation was significantly higher than that seen in pure urothelial carcinoma (46.2% vs 27.0%; P = .04).
Urothelial carcinoma with squamous differentiation is associated with advanced tumor stage. In addition, urothelial carcinoma with extensive squamous differentiation presented with a significantly higher rate of nodal metastasis. These findings can be the contributing factors for the unfavorable clinical outcomes seen in patients with urothelial carcinoma and squamous differentiation.</abstract><cop>United States</cop><pmid>28178718</pmid><doi>10.1177/107327481702400113</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Carcinoma, Squamous Cell - secondary Carcinoma, Squamous Cell - surgery Cell Differentiation Cystectomy Female Follow-Up Studies Humans Lymph Nodes - pathology Lymph Nodes - surgery Lymphatic Metastasis Male Middle Aged Neoplasm Invasiveness Neoplasm Staging Pelvic Neoplasms - secondary Pelvic Neoplasms - surgery Prognosis Retrospective Studies Urinary Bladder Neoplasms - pathology Urinary Bladder Neoplasms - surgery |
| title | Urothelial Carcinoma With Squamous Differentiation Is Associated With High Tumor Stage and Pelvic Lymph-Node Metastasis |
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