Phosphinic, phosphonic and seleninic acid bioisosteres of isonipecotic acid as novel and selective GABA sub(C) receptor antagonists

A number of amino acids bioisosterically derived from the specific GABA sub(A) agonist, isonipecotic acid, were electrophysiologically characterized as antagonists at GABA sub(C) rho sub(1) receptors expressed in Xenopus oocytes. The phosphinic acid analogue of isonipecotic acid, piperidin-4-ylphosp...

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Veröffentlicht in:	Neurochemistry international 2003-06, Vol.42 (7), p.561-565
Hauptverfasser:	Krehan, D, Froelund, B, Krogsgaard-Larsen, P, Kehler, J, Johnston, GAR, Chebib, M
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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