ARResT/Interrogate: an interactive immunoprofiler for IG/TR NGS data

The study of immunoglobulins and T cell receptors using next-generation sequencing has finally allowed exploring immune repertoires and responses in their immense variability and complexity. Unsurprisingly, their analysis and interpretation is a highly convoluted task. We thus implemented ARResT/Int...

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Veröffentlicht in:Bioinformatics (Oxford, England) England), 2017-02, Vol.33 (3), p.435-437
Hauptverfasser: Bystry, Vojtech, Reigl, Tomas, Krejci, Adam, Demko, Martin, Hanakova, Barbora, Grioni, Andrea, Knecht, Henrik, Schlitt, Max, Dreger, Peter, Sellner, Leopold, Herrmann, Dietrich, Pingeon, Marine, Boudjoghra, Myriam, Rijntjes, Jos, Pott, Christiane, Langerak, Anton W, Groenen, Patricia J T A, Davi, Frederic, Brüggemann, Monika, Darzentas, Nikos
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Sprache:eng
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Zusammenfassung:The study of immunoglobulins and T cell receptors using next-generation sequencing has finally allowed exploring immune repertoires and responses in their immense variability and complexity. Unsurprisingly, their analysis and interpretation is a highly convoluted task. We thus implemented ARResT/Interrogate, a web-based, interactive application. It can organize and filter large amounts of immunogenetic data by numerous criteria, calculate several relevant statistics, and present results in the form of multiple interconnected visualizations. ARResT/Interrogate is implemented primarily in R, and is freely available at http://bat.infspire.org/arrest/interrogate/ nikos.darzentas@gmail.com Supplementary data are available at Bioinformatics online.
ISSN:1367-4803
1367-4811
DOI:10.1093/bioinformatics/btw634