Biological reactivity and biomarkers of the neutrophil oxidant, hypochlorous acid

Free radicals or reactive oxygen species are thought to contribute to the pathology of many diseases. These include inflammatory conditions, where neutrophils accumulate in large numbers and are stimulated to produce superoxide and other reactive oxidants. Hypochlorous acid (HOCl), produced by myelo...

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Veröffentlicht in:	Toxicology (Amsterdam) 2002-12, Vol.181, p.223-227
1. Verfasser:	Winterbourn, Christine C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Biomarkers Chemical and industrial products toxicology. Toxic occupational diseases Chlorohydrins - chemistry Chlorohydrins - metabolism Chlorotyrosine Glutathione Humans Hypochlorous acid Hypochlorous Acid - chemistry Hypochlorous Acid - metabolism Hypochlorous Acid - toxicity Medical sciences Metals and various inorganic compounds Myeloperoxidase Neutrophil Neutrophils - drug effects Oxidants - toxicity Oxidation-Reduction Proteins - chemistry Proteins - immunology Sulfhydryl Compounds - chemistry Toxicology Tyrosine - chemistry Tyrosine - metabolism
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