Genetic polymorphisms of alcohol and aldehyde dehydrogenases and glutathione S-transferase M1 and drinking, smoking, and diet in Japanese men with esophageal squamous cell carcinoma

The genetic polymorphisms of aldehyde dehydrogenase-2 (ALDH2), alcohol dehydrogenase-2 (ADH2), ADH3, and glutathione S-transferase M1 (GSTM1) influence the metabolism of alcohol and other carcinogens. The ALDH2*1/2*2 genotype, which encodes inactive ALDH2, and ADH2*1/2*1, which encodes the low-activ...

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Veröffentlicht in:	Carcinogenesis (New York) 2002-11, Vol.23 (11), p.1851-1859
Hauptverfasser:	Yokoyama, Akira, Kato, Hoichi, Yokoyama, Tetsuji, Tsujinaka, Toshimasa, Muto, Manabu, Omori, Tai, Haneda, Tatsumasa, Kumagai, Yoshiya, Igaki, Hiroyasu, Yokoyama, Masako, Watanabe, Hiroshi, Fukuda, Haruhiko, Yoshimizu, Haruko
Format:	Artikel
Sprache:	eng
Schlagworte:	ADH Adult Aged alcohol dehydrogenase Alcohol Dehydrogenase - genetics Alcohol Drinking - epidemiology aldehyde dehydrogenase Aldehyde Dehydrogenase - deficiency Aldehyde Dehydrogenase - genetics Aldehyde Dehydrogenase, Mitochondrial ALDH Biological and medical sciences Carcinoma, Squamous Cell - enzymology Carcinoma, Squamous Cell - epidemiology Carcinoma, Squamous Cell - genetics Case-Control Studies confidence interval. GSTM1 Diet - statistics & numerical data Esophageal Neoplasms - enzymology Esophageal Neoplasms - epidemiology Esophageal Neoplasms - genetics Esophagus Flushing - chemically induced Flushing - enzymology Flushing - genetics Fruit Gastroenterology. Liver. Pancreas. Abdomen Genetic Predisposition to Disease Genotype glutathione S-transferase M1 Glutathione Transferase - genetics Hot Temperature Humans Isoenzymes - genetics Japan - epidemiology Male Medical sciences Middle Aged Odds Ratio PAR Polymorphism, Genetic population-attributable risk Risk Factors Smoking - epidemiology Surveys and Questionnaires Tumors Vegetables
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