Zinc Sulfate and/or Growth Hormone Administration for the Prevention of Radiation-Induced Dermatitis: a Placebo-Controlled Rat Model Study
Growth hormone ( GH ) and zinc ( Zn) were evaluated for their potential to prevent radiation injury using a rat model of radiation-induced skin injury. Sprague–Dawley rats were divided into five groups: a control group not receiving Zn, GH, or irradiation: a radiation (RT) group receiving a single 3...
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| Veröffentlicht in: | Biological trace element research 2017-09, Vol.179 (1), p.110-116 |
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| creator | Kandaz, Mustafa Ertekin, Mustafa Vecdi Karslıoğlu, İhsan Erdoğan, Fazlı Sezen, Orhan Gepdiremen, Akçahan Gündoğdu, Cemal |
| description | Growth hormone
(
GH
)
and zinc
(
Zn) were evaluated for their potential to prevent radiation injury using a rat model of radiation-induced skin injury. Sprague–Dawley rats were divided into five groups: a control group not receiving Zn, GH, or irradiation: a radiation (RT) group receiving a single 30 Gy dose of gamma irradiation to the right hind legs; a radiation + GH group (RT + GH) receiving a single 30 Gy dose of gamma irradiation plus the subcutaneous administration of 0.01 IU kg d
−1
GH; a radiation + Zn group (RT + Zn) receiving a single 30 Gy dose plus 5 mg kg d
−1
Zn po; and a radiation + GH + Zn group (RT + GH + Zn) group receiving a single 30 Gy dose plus subcutaneous 0.01 IU kg d
−1
GH and 5 mg kg d
−1
Zn po. Acute skin reactions were assessed every 3 days by two radiation oncologists grouping. Light microscopic findings were assessed blindly by two pathologists. Groups receiving irradiation were associated with dermatitis as compared to the control group (
P
|
| doi_str_mv | 10.1007/s12011-017-0952-z |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1865826971</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1865826971</sourcerecordid><originalsourceid>FETCH-LOGICAL-c372t-e223e6001a185da527c9bd774c3d13defa81b1dfdbed11c42e1c31d2c4dabff63</originalsourceid><addsrcrecordid>eNp1kU9PFjEQxhsjkVfwA3gxTbx4KXTa3e2uN_KqQAKRAF68NN12Vpbstth2NfAR_NQWXjSGxNMkM7955s9DyGvge8C52k8gOADjoBjvasHunpEV1HXHuBL8OVlxaCSrurbaJi9TuuYFFJ18QbZFC01bS7kiv76O3tKLZRpMRmq82w-RHsbwM1_RoxDn4JEeuHn0Y8rR5DF4OhQiXyE9i_gD_UMqDPTcuPGhzo69Wyw6-gHjXDJ5TO-poWeTsdgHtg4-xzBNBTg3mZ4GhxO9yIu73SVbg5kSvnqMO-TLp4-X6yN28vnweH1wwqxUIjMUQmJTbjHQ1s7UQtmud0pVVjqQDgfTQg9ucD06AFsJBCvBCVs50w9DI3fIu43uTQzfF0xZz2OyOE3GY1iShrapW9F0Cgr69gl6HZboy3YaOqEqXlVSFQo2lI0hpYiDvonjbOKtBq7vjdIbo3T5v743St-VnjePyks_o_vb8ceZAogNkErJf8P4z-j_qv4G6_agag</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1927404437</pqid></control><display><type>article</type><title>Zinc Sulfate and/or Growth Hormone Administration for the Prevention of Radiation-Induced Dermatitis: a Placebo-Controlled Rat Model Study</title><source>SpringerLink Journals - AutoHoldings</source><creator>Kandaz, Mustafa ; Ertekin, Mustafa Vecdi ; Karslıoğlu, İhsan ; Erdoğan, Fazlı ; Sezen, Orhan ; Gepdiremen, Akçahan ; Gündoğdu, Cemal</creator><creatorcontrib>Kandaz, Mustafa ; Ertekin, Mustafa Vecdi ; Karslıoğlu, İhsan ; Erdoğan, Fazlı ; Sezen, Orhan ; Gepdiremen, Akçahan ; Gündoğdu, Cemal</creatorcontrib><description>Growth hormone
(
GH
)
and zinc
(
Zn) were evaluated for their potential to prevent radiation injury using a rat model of radiation-induced skin injury. Sprague–Dawley rats were divided into five groups: a control group not receiving Zn, GH, or irradiation: a radiation (RT) group receiving a single 30 Gy dose of gamma irradiation to the right hind legs; a radiation + GH group (RT + GH) receiving a single 30 Gy dose of gamma irradiation plus the subcutaneous administration of 0.01 IU kg d
−1
GH; a radiation + Zn group (RT + Zn) receiving a single 30 Gy dose plus 5 mg kg d
−1
Zn po; and a radiation + GH + Zn group (RT + GH + Zn) group receiving a single 30 Gy dose plus subcutaneous 0.01 IU kg d
−1
GH and 5 mg kg d
−1
Zn po. Acute skin reactions were assessed every 3 days by two radiation oncologists grouping. Light microscopic findings were assessed blindly by two pathologists. Groups receiving irradiation were associated with dermatitis as compared to the control group (
P
< 0.05). The severity of radiodermatitis in the RT + GH, RT + Zn, and RT + GH + Zn groups was significantly lower than that in the RT group (
P
< 0.05). Furthermore, radiodermatitis was observed earlier in the RT group than in the other treatment groups (
P
< 0.05). GH and Zn effectively prevented epidermal atrophy, dermal degeneration, and hair follicle atrophy. The highest level of protection against radiation dermatitis was observed in the combination group.</description><identifier>ISSN: 0163-4984</identifier><identifier>EISSN: 1559-0720</identifier><identifier>DOI: 10.1007/s12011-017-0952-z</identifier><identifier>PMID: 28168533</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Atrophy ; Biochemistry ; Biomedical and Life Sciences ; Biotechnology ; Degeneration ; Dermatitis ; Disease prevention ; Gamma irradiation ; Gamma rays ; Growth hormones ; Hair ; Injury prevention ; Irradiation ; Legs ; Life Sciences ; Nutrition ; Oncology ; Radiation effects ; Radiation injuries ; Rats ; Skin injuries ; Sulfates ; Zinc ; Zinc sulfate</subject><ispartof>Biological trace element research, 2017-09, Vol.179 (1), p.110-116</ispartof><rights>Springer Science+Business Media New York 2017</rights><rights>Biological Trace Element Research is a copyright of Springer, 2017.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-e223e6001a185da527c9bd774c3d13defa81b1dfdbed11c42e1c31d2c4dabff63</citedby><cites>FETCH-LOGICAL-c372t-e223e6001a185da527c9bd774c3d13defa81b1dfdbed11c42e1c31d2c4dabff63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12011-017-0952-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12011-017-0952-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28168533$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kandaz, Mustafa</creatorcontrib><creatorcontrib>Ertekin, Mustafa Vecdi</creatorcontrib><creatorcontrib>Karslıoğlu, İhsan</creatorcontrib><creatorcontrib>Erdoğan, Fazlı</creatorcontrib><creatorcontrib>Sezen, Orhan</creatorcontrib><creatorcontrib>Gepdiremen, Akçahan</creatorcontrib><creatorcontrib>Gündoğdu, Cemal</creatorcontrib><title>Zinc Sulfate and/or Growth Hormone Administration for the Prevention of Radiation-Induced Dermatitis: a Placebo-Controlled Rat Model Study</title><title>Biological trace element research</title><addtitle>Biol Trace Elem Res</addtitle><addtitle>Biol Trace Elem Res</addtitle><description>Growth hormone
(
GH
)
and zinc
(
Zn) were evaluated for their potential to prevent radiation injury using a rat model of radiation-induced skin injury. Sprague–Dawley rats were divided into five groups: a control group not receiving Zn, GH, or irradiation: a radiation (RT) group receiving a single 30 Gy dose of gamma irradiation to the right hind legs; a radiation + GH group (RT + GH) receiving a single 30 Gy dose of gamma irradiation plus the subcutaneous administration of 0.01 IU kg d
−1
GH; a radiation + Zn group (RT + Zn) receiving a single 30 Gy dose plus 5 mg kg d
−1
Zn po; and a radiation + GH + Zn group (RT + GH + Zn) group receiving a single 30 Gy dose plus subcutaneous 0.01 IU kg d
−1
GH and 5 mg kg d
−1
Zn po. Acute skin reactions were assessed every 3 days by two radiation oncologists grouping. Light microscopic findings were assessed blindly by two pathologists. Groups receiving irradiation were associated with dermatitis as compared to the control group (
P
< 0.05). The severity of radiodermatitis in the RT + GH, RT + Zn, and RT + GH + Zn groups was significantly lower than that in the RT group (
P
< 0.05). Furthermore, radiodermatitis was observed earlier in the RT group than in the other treatment groups (
P
< 0.05). GH and Zn effectively prevented epidermal atrophy, dermal degeneration, and hair follicle atrophy. The highest level of protection against radiation dermatitis was observed in the combination group.</description><subject>Atrophy</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biotechnology</subject><subject>Degeneration</subject><subject>Dermatitis</subject><subject>Disease prevention</subject><subject>Gamma irradiation</subject><subject>Gamma rays</subject><subject>Growth hormones</subject><subject>Hair</subject><subject>Injury prevention</subject><subject>Irradiation</subject><subject>Legs</subject><subject>Life Sciences</subject><subject>Nutrition</subject><subject>Oncology</subject><subject>Radiation effects</subject><subject>Radiation injuries</subject><subject>Rats</subject><subject>Skin injuries</subject><subject>Sulfates</subject><subject>Zinc</subject><subject>Zinc sulfate</subject><issn>0163-4984</issn><issn>1559-0720</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNp1kU9PFjEQxhsjkVfwA3gxTbx4KXTa3e2uN_KqQAKRAF68NN12Vpbstth2NfAR_NQWXjSGxNMkM7955s9DyGvge8C52k8gOADjoBjvasHunpEV1HXHuBL8OVlxaCSrurbaJi9TuuYFFJ18QbZFC01bS7kiv76O3tKLZRpMRmq82w-RHsbwM1_RoxDn4JEeuHn0Y8rR5DF4OhQiXyE9i_gD_UMqDPTcuPGhzo69Wyw6-gHjXDJ5TO-poWeTsdgHtg4-xzBNBTg3mZ4GhxO9yIu73SVbg5kSvnqMO-TLp4-X6yN28vnweH1wwqxUIjMUQmJTbjHQ1s7UQtmud0pVVjqQDgfTQg9ucD06AFsJBCvBCVs50w9DI3fIu43uTQzfF0xZz2OyOE3GY1iShrapW9F0Cgr69gl6HZboy3YaOqEqXlVSFQo2lI0hpYiDvonjbOKtBq7vjdIbo3T5v743St-VnjePyks_o_vb8ceZAogNkErJf8P4z-j_qv4G6_agag</recordid><startdate>20170901</startdate><enddate>20170901</enddate><creator>Kandaz, Mustafa</creator><creator>Ertekin, Mustafa Vecdi</creator><creator>Karslıoğlu, İhsan</creator><creator>Erdoğan, Fazlı</creator><creator>Sezen, Orhan</creator><creator>Gepdiremen, Akçahan</creator><creator>Gündoğdu, Cemal</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QH</scope><scope>7QP</scope><scope>7TN</scope><scope>7U7</scope><scope>7UA</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BKSAR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>F1W</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H97</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>L.G</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PCBAR</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20170901</creationdate><title>Zinc Sulfate and/or Growth Hormone Administration for the Prevention of Radiation-Induced Dermatitis: a Placebo-Controlled Rat Model Study</title><author>Kandaz, Mustafa ; Ertekin, Mustafa Vecdi ; Karslıoğlu, İhsan ; Erdoğan, Fazlı ; Sezen, Orhan ; Gepdiremen, Akçahan ; Gündoğdu, Cemal</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-e223e6001a185da527c9bd774c3d13defa81b1dfdbed11c42e1c31d2c4dabff63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Atrophy</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Biotechnology</topic><topic>Degeneration</topic><topic>Dermatitis</topic><topic>Disease prevention</topic><topic>Gamma irradiation</topic><topic>Gamma rays</topic><topic>Growth hormones</topic><topic>Hair</topic><topic>Injury prevention</topic><topic>Irradiation</topic><topic>Legs</topic><topic>Life Sciences</topic><topic>Nutrition</topic><topic>Oncology</topic><topic>Radiation effects</topic><topic>Radiation injuries</topic><topic>Rats</topic><topic>Skin injuries</topic><topic>Sulfates</topic><topic>Zinc</topic><topic>Zinc sulfate</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kandaz, Mustafa</creatorcontrib><creatorcontrib>Ertekin, Mustafa Vecdi</creatorcontrib><creatorcontrib>Karslıoğlu, İhsan</creatorcontrib><creatorcontrib>Erdoğan, Fazlı</creatorcontrib><creatorcontrib>Sezen, Orhan</creatorcontrib><creatorcontrib>Gepdiremen, Akçahan</creatorcontrib><creatorcontrib>Gündoğdu, Cemal</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Aqualine</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Oceanic Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Water Resources 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Radiation-Induced Dermatitis: a Placebo-Controlled Rat Model Study</atitle><jtitle>Biological trace element research</jtitle><stitle>Biol Trace Elem Res</stitle><addtitle>Biol Trace Elem Res</addtitle><date>2017-09-01</date><risdate>2017</risdate><volume>179</volume><issue>1</issue><spage>110</spage><epage>116</epage><pages>110-116</pages><issn>0163-4984</issn><eissn>1559-0720</eissn><abstract>Growth hormone
(
GH
)
and zinc
(
Zn) were evaluated for their potential to prevent radiation injury using a rat model of radiation-induced skin injury. Sprague–Dawley rats were divided into five groups: a control group not receiving Zn, GH, or irradiation: a radiation (RT) group receiving a single 30 Gy dose of gamma irradiation to the right hind legs; a radiation + GH group (RT + GH) receiving a single 30 Gy dose of gamma irradiation plus the subcutaneous administration of 0.01 IU kg d
−1
GH; a radiation + Zn group (RT + Zn) receiving a single 30 Gy dose plus 5 mg kg d
−1
Zn po; and a radiation + GH + Zn group (RT + GH + Zn) group receiving a single 30 Gy dose plus subcutaneous 0.01 IU kg d
−1
GH and 5 mg kg d
−1
Zn po. Acute skin reactions were assessed every 3 days by two radiation oncologists grouping. Light microscopic findings were assessed blindly by two pathologists. Groups receiving irradiation were associated with dermatitis as compared to the control group (
P
< 0.05). The severity of radiodermatitis in the RT + GH, RT + Zn, and RT + GH + Zn groups was significantly lower than that in the RT group (
P
< 0.05). Furthermore, radiodermatitis was observed earlier in the RT group than in the other treatment groups (
P
< 0.05). GH and Zn effectively prevented epidermal atrophy, dermal degeneration, and hair follicle atrophy. The highest level of protection against radiation dermatitis was observed in the combination group.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>28168533</pmid><doi>10.1007/s12011-017-0952-z</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Biological trace element research, 2017-09, Vol.179 (1), p.110-116 |
| issn | 0163-4984 1559-0720 |
| language | eng |
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| source | SpringerLink Journals - AutoHoldings |
| subjects | Atrophy Biochemistry Biomedical and Life Sciences Biotechnology Degeneration Dermatitis Disease prevention Gamma irradiation Gamma rays Growth hormones Hair Injury prevention Irradiation Legs Life Sciences Nutrition Oncology Radiation effects Radiation injuries Rats Skin injuries Sulfates Zinc Zinc sulfate |
| title | Zinc Sulfate and/or Growth Hormone Administration for the Prevention of Radiation-Induced Dermatitis: a Placebo-Controlled Rat Model Study |
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