Non-contrast magnetic resonance imaging for bladder cancer: fused high b value diffusion-weighted imaging and T2-weighted imaging helps evaluate depth of invasion

Objects To investigate the utility of fused high b value diffusion-weighted imaging (DWI) and T2-weighted imaging (T2WI) for evaluating depth of invasion in bladder cancer. Methods We included 62 patients with magnetic resonance imaging (MRI) and surgically confirmed urothelial carcinoma in the urin...

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Veröffentlicht in:European radiology 2017-09, Vol.27 (9), p.3752-3758
Hauptverfasser: Lee, Minsu, Shin, Su-Jin, Oh, Young Taik, Jung, Dae Chul, Cho, Nam Hoon, Choi, Young Deuk, Park, Sung Yoon
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container_issue 9
container_start_page 3752
container_title European radiology
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creator Lee, Minsu
Shin, Su-Jin
Oh, Young Taik
Jung, Dae Chul
Cho, Nam Hoon
Choi, Young Deuk
Park, Sung Yoon
description Objects To investigate the utility of fused high b value diffusion-weighted imaging (DWI) and T2-weighted imaging (T2WI) for evaluating depth of invasion in bladder cancer. Methods We included 62 patients with magnetic resonance imaging (MRI) and surgically confirmed urothelial carcinoma in the urinary bladder. An experienced genitourinary radiologist analysed the depth of invasion (T stage
doi_str_mv 10.1007/s00330-017-4759-2
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Methods We included 62 patients with magnetic resonance imaging (MRI) and surgically confirmed urothelial carcinoma in the urinary bladder. An experienced genitourinary radiologist analysed the depth of invasion (T stage &lt;2 or ≥2) using T2WI, DWI, T2WI plus DWI, and fused DWI and T2WI (fusion MRI). Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and accuracy were investigated. Area under the curve (AUC) was analysed to identify T stage ≥2. Results The rate of patients with surgically confirmed T stage ≥2 was 41.9% (26/62). Sensitivity, specificity, PPV, NPV and accuracy were 50.0%, 55.6%, 44.8%, 60.6% and 53.2%, respectively, with T2WI; 57.7%, 77.8%, 65.2%, 71.8% and 69.4%, respectively, with DWI; 65.4%, 80.6%, 70.8%, 76.3% and 74.2%, respectively, with T2WI plus DWI and 80.8%, 77.8%, 72.4%, 84.9% and 79.0%, respectively, with fusion MRI. AUC was 0.528 with T2WI, 0.677 with DWI, 0.730 with T2WI plus DWI and 0.793 with fusion MRI for T stage ≥2. Conclusion Fused high b value DWI and T2WI may be a promising non-contrast MRI technique for assessing depth of invasion in bladder cancer. Key Points • Accuracy of fusion MRI was 79.0% for T stage ≥2 in bladder cancer . • AUC of fusion MRI was 0.793 for T stage ≥2 in bladder cancer . • Diagnostic performance of fusion MRI was comparable with T2WI plus DWI . • As a non-contrast MRI technique, fusion MRI is useful for bladder cancer .</description><identifier>ISSN: 0938-7994</identifier><identifier>EISSN: 1432-1084</identifier><identifier>DOI: 10.1007/s00330-017-4759-2</identifier><identifier>PMID: 28168374</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Accuracy ; Adult ; Aged ; Aged, 80 and over ; Area Under Curve ; Bladder ; Bladder cancer ; Cancer ; Carcinoma - diagnostic imaging ; Carcinoma - pathology ; Diagnostic Radiology ; Diagnostic systems ; Diffusion Magnetic Resonance Imaging - methods ; Female ; Health risk assessment ; Humans ; Imaging ; Internal Medicine ; Interventional Radiology ; Magnetic resonance imaging ; Magnetic Resonance Imaging - methods ; Magnetic Resonance Imaging - standards ; Male ; Medicine ; Medicine &amp; Public Health ; Middle Aged ; Neuroradiology ; NMR ; Nuclear magnetic resonance ; Patients ; Predictive Value of Tests ; Radiology ; Resonance ; Retrospective Studies ; Sensitivity ; Sensitivity and Specificity ; Ultrasound ; Urethral Neoplasms - diagnostic imaging ; Urethral Neoplasms - pathology ; Urinary bladder ; Urinary Bladder Neoplasms - diagnostic imaging ; Urinary Bladder Neoplasms - pathology ; Urogenital ; Urothelial carcinoma</subject><ispartof>European radiology, 2017-09, Vol.27 (9), p.3752-3758</ispartof><rights>European Society of Radiology 2017</rights><rights>European Radiology is a copyright of Springer, 2017.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-ed2e2d737b439e2c6d1e6c420801a2ff2d9852cfad2b2241323c35f2c789e3883</citedby><cites>FETCH-LOGICAL-c438t-ed2e2d737b439e2c6d1e6c420801a2ff2d9852cfad2b2241323c35f2c789e3883</cites><orcidid>0000-0002-1322-0526</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00330-017-4759-2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00330-017-4759-2$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28168374$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, Minsu</creatorcontrib><creatorcontrib>Shin, Su-Jin</creatorcontrib><creatorcontrib>Oh, Young Taik</creatorcontrib><creatorcontrib>Jung, Dae Chul</creatorcontrib><creatorcontrib>Cho, Nam Hoon</creatorcontrib><creatorcontrib>Choi, Young Deuk</creatorcontrib><creatorcontrib>Park, Sung Yoon</creatorcontrib><title>Non-contrast magnetic resonance imaging for bladder cancer: fused high b value diffusion-weighted imaging and T2-weighted imaging helps evaluate depth of invasion</title><title>European radiology</title><addtitle>Eur Radiol</addtitle><addtitle>Eur Radiol</addtitle><description>Objects To investigate the utility of fused high b value diffusion-weighted imaging (DWI) and T2-weighted imaging (T2WI) for evaluating depth of invasion in bladder cancer. Methods We included 62 patients with magnetic resonance imaging (MRI) and surgically confirmed urothelial carcinoma in the urinary bladder. An experienced genitourinary radiologist analysed the depth of invasion (T stage &lt;2 or ≥2) using T2WI, DWI, T2WI plus DWI, and fused DWI and T2WI (fusion MRI). Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and accuracy were investigated. Area under the curve (AUC) was analysed to identify T stage ≥2. Results The rate of patients with surgically confirmed T stage ≥2 was 41.9% (26/62). Sensitivity, specificity, PPV, NPV and accuracy were 50.0%, 55.6%, 44.8%, 60.6% and 53.2%, respectively, with T2WI; 57.7%, 77.8%, 65.2%, 71.8% and 69.4%, respectively, with DWI; 65.4%, 80.6%, 70.8%, 76.3% and 74.2%, respectively, with T2WI plus DWI and 80.8%, 77.8%, 72.4%, 84.9% and 79.0%, respectively, with fusion MRI. AUC was 0.528 with T2WI, 0.677 with DWI, 0.730 with T2WI plus DWI and 0.793 with fusion MRI for T stage ≥2. Conclusion Fused high b value DWI and T2WI may be a promising non-contrast MRI technique for assessing depth of invasion in bladder cancer. Key Points • Accuracy of fusion MRI was 79.0% for T stage ≥2 in bladder cancer . • AUC of fusion MRI was 0.793 for T stage ≥2 in bladder cancer . • Diagnostic performance of fusion MRI was comparable with T2WI plus DWI . • As a non-contrast MRI technique, fusion MRI is useful for bladder cancer .</description><subject>Accuracy</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Area Under Curve</subject><subject>Bladder</subject><subject>Bladder cancer</subject><subject>Cancer</subject><subject>Carcinoma - diagnostic imaging</subject><subject>Carcinoma - pathology</subject><subject>Diagnostic Radiology</subject><subject>Diagnostic systems</subject><subject>Diffusion Magnetic Resonance Imaging - methods</subject><subject>Female</subject><subject>Health risk assessment</subject><subject>Humans</subject><subject>Imaging</subject><subject>Internal Medicine</subject><subject>Interventional Radiology</subject><subject>Magnetic resonance imaging</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Magnetic Resonance Imaging - standards</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine &amp; Public Health</subject><subject>Middle Aged</subject><subject>Neuroradiology</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Patients</subject><subject>Predictive Value of Tests</subject><subject>Radiology</subject><subject>Resonance</subject><subject>Retrospective Studies</subject><subject>Sensitivity</subject><subject>Sensitivity and Specificity</subject><subject>Ultrasound</subject><subject>Urethral Neoplasms - diagnostic imaging</subject><subject>Urethral Neoplasms - pathology</subject><subject>Urinary bladder</subject><subject>Urinary Bladder Neoplasms - diagnostic imaging</subject><subject>Urinary Bladder Neoplasms - pathology</subject><subject>Urogenital</subject><subject>Urothelial carcinoma</subject><issn>0938-7994</issn><issn>1432-1084</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kcuOFCEUhonROO3oA7gxJG7coHCgGnBnJt6SiW7GNaHg0F2TaqqFqpn4Oj6pVHrGGI0rkv_yAfkJeS74a8G5flM5l5IzLjRTurMMHpCNUBKY4EY9JBtupWHaWnVGntR6zTm3QunH5AyM2Bqp1Yb8_DJlFqY8F19nevC7jPMQaME6ZZ8D0qFpQ97RNBXajz5GLDSsTnlL01Ix0v2w29Oe3vhxQRqH1NShQW-x6XPz7wk-R3oF_-p7HI-V4tr3cyPgcd7TKdEh3_iV9JQ8Sn6s-OzuPCffPry_uvjELr9-_Hzx7pIFJc3MMAJC1FL3SlqEsI0Ct0EBN1x4SAmiNR2E5CP0AEpIkEF2CYI2FqUx8py8OnGPZfq-YJ3dYagBx9FnnJbqhNl2pjWVbdGXf0Wvp6Xk9jonLHRWg-10S4lTKpSp1oLJHUv7dPnhBHfrgO40oGsDunVAB63z4o689AeMvxv3i7UAnAK1WXmH5Y-r_0v9Bfokp-w</recordid><startdate>20170901</startdate><enddate>20170901</enddate><creator>Lee, Minsu</creator><creator>Shin, Su-Jin</creator><creator>Oh, Young Taik</creator><creator>Jung, Dae Chul</creator><creator>Cho, Nam Hoon</creator><creator>Choi, Young Deuk</creator><creator>Park, Sung Yoon</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-1322-0526</orcidid></search><sort><creationdate>20170901</creationdate><title>Non-contrast magnetic resonance imaging for bladder cancer: fused high b value diffusion-weighted imaging and T2-weighted imaging helps evaluate depth of invasion</title><author>Lee, Minsu ; Shin, Su-Jin ; Oh, Young Taik ; Jung, Dae Chul ; Cho, Nam Hoon ; Choi, Young Deuk ; Park, Sung Yoon</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c438t-ed2e2d737b439e2c6d1e6c420801a2ff2d9852cfad2b2241323c35f2c789e3883</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Accuracy</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Area Under Curve</topic><topic>Bladder</topic><topic>Bladder cancer</topic><topic>Cancer</topic><topic>Carcinoma - diagnostic imaging</topic><topic>Carcinoma - pathology</topic><topic>Diagnostic Radiology</topic><topic>Diagnostic systems</topic><topic>Diffusion Magnetic Resonance Imaging - methods</topic><topic>Female</topic><topic>Health risk assessment</topic><topic>Humans</topic><topic>Imaging</topic><topic>Internal Medicine</topic><topic>Interventional Radiology</topic><topic>Magnetic resonance imaging</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Magnetic Resonance Imaging - standards</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine &amp; 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Medical Complete (Alumni)</collection><collection>Nursing &amp; Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>Advanced Technologies &amp; Aerospace Database</collection><collection>ProQuest Advanced Technologies &amp; Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>European radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Minsu</au><au>Shin, Su-Jin</au><au>Oh, Young Taik</au><au>Jung, Dae Chul</au><au>Cho, Nam Hoon</au><au>Choi, Young Deuk</au><au>Park, Sung Yoon</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Non-contrast magnetic resonance imaging for bladder cancer: fused high b value diffusion-weighted imaging and T2-weighted imaging helps evaluate depth of invasion</atitle><jtitle>European radiology</jtitle><stitle>Eur Radiol</stitle><addtitle>Eur Radiol</addtitle><date>2017-09-01</date><risdate>2017</risdate><volume>27</volume><issue>9</issue><spage>3752</spage><epage>3758</epage><pages>3752-3758</pages><issn>0938-7994</issn><eissn>1432-1084</eissn><abstract>Objects To investigate the utility of fused high b value diffusion-weighted imaging (DWI) and T2-weighted imaging (T2WI) for evaluating depth of invasion in bladder cancer. Methods We included 62 patients with magnetic resonance imaging (MRI) and surgically confirmed urothelial carcinoma in the urinary bladder. An experienced genitourinary radiologist analysed the depth of invasion (T stage &lt;2 or ≥2) using T2WI, DWI, T2WI plus DWI, and fused DWI and T2WI (fusion MRI). Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and accuracy were investigated. Area under the curve (AUC) was analysed to identify T stage ≥2. Results The rate of patients with surgically confirmed T stage ≥2 was 41.9% (26/62). Sensitivity, specificity, PPV, NPV and accuracy were 50.0%, 55.6%, 44.8%, 60.6% and 53.2%, respectively, with T2WI; 57.7%, 77.8%, 65.2%, 71.8% and 69.4%, respectively, with DWI; 65.4%, 80.6%, 70.8%, 76.3% and 74.2%, respectively, with T2WI plus DWI and 80.8%, 77.8%, 72.4%, 84.9% and 79.0%, respectively, with fusion MRI. AUC was 0.528 with T2WI, 0.677 with DWI, 0.730 with T2WI plus DWI and 0.793 with fusion MRI for T stage ≥2. Conclusion Fused high b value DWI and T2WI may be a promising non-contrast MRI technique for assessing depth of invasion in bladder cancer. Key Points • Accuracy of fusion MRI was 79.0% for T stage ≥2 in bladder cancer . • AUC of fusion MRI was 0.793 for T stage ≥2 in bladder cancer . • Diagnostic performance of fusion MRI was comparable with T2WI plus DWI . • As a non-contrast MRI technique, fusion MRI is useful for bladder cancer .</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>28168374</pmid><doi>10.1007/s00330-017-4759-2</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-1322-0526</orcidid></addata></record>
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subjects Accuracy
Adult
Aged
Aged, 80 and over
Area Under Curve
Bladder
Bladder cancer
Cancer
Carcinoma - diagnostic imaging
Carcinoma - pathology
Diagnostic Radiology
Diagnostic systems
Diffusion Magnetic Resonance Imaging - methods
Female
Health risk assessment
Humans
Imaging
Internal Medicine
Interventional Radiology
Magnetic resonance imaging
Magnetic Resonance Imaging - methods
Magnetic Resonance Imaging - standards
Male
Medicine
Medicine & Public Health
Middle Aged
Neuroradiology
NMR
Nuclear magnetic resonance
Patients
Predictive Value of Tests
Radiology
Resonance
Retrospective Studies
Sensitivity
Sensitivity and Specificity
Ultrasound
Urethral Neoplasms - diagnostic imaging
Urethral Neoplasms - pathology
Urinary bladder
Urinary Bladder Neoplasms - diagnostic imaging
Urinary Bladder Neoplasms - pathology
Urogenital
Urothelial carcinoma
title Non-contrast magnetic resonance imaging for bladder cancer: fused high b value diffusion-weighted imaging and T2-weighted imaging helps evaluate depth of invasion
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