Testosterone promotes tube formation of endothelial cells isolated from veins via activation of Smad1 protein

Testosterone (T) deficiency is positively correlated with the increased incidence of cardiovascular disease. However, the effects of T on vascular endothelial cells remain obscure. Tube formation capacity is critical for vascular regeneration/repair and Smad1 plays an important role in these events....

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Veröffentlicht in:	Molecular and cellular endocrinology 2017-05, Vol.446, p.21-31
Hauptverfasser:	Liu, Pei, Li, Xiaosa, Song, Fuhu, Li, Ping, Wei, Jinzhi, Yan, Qing, Xu, Xingyan, Yang, Jun, Li, Chuanxiang, Fu, Xiaodong
Format:	Artikel
Sprache:	eng
Schlagworte:	Caveolin 1 - metabolism Caveolin-1 Cell Nucleus - drug effects Cell Nucleus - metabolism Cell Separation Extracellular Signal-Regulated MAP Kinases - metabolism Human Umbilical Vein Endothelial Cells - drug effects Human Umbilical Vein Endothelial Cells - metabolism Humans Models, Biological Neovascularization, Physiologic - drug effects Phosphorylation - drug effects Receptors, Androgen - metabolism Signal Transduction - drug effects Smad1 Smad1 Protein - metabolism src-Family Kinases - metabolism Testosterone Testosterone - pharmacology Tube formation Vascular endothelial cells Veins Veins - cytology
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