Intranasal Pretreatment with Z‑Ligustilide, the Main Volatile Component of Rhizoma Chuanxiong, Confers Prophylaxis against Cerebral Ischemia via Nrf2 and HSP70 Signaling Pathways
Z-Ligustilide (Z-LIG) is a major component in Rhizoma Chuanxiong, which has been traditionally used as a health food supplement for the prevention of cerebrovascular disease in China. This study investigates the ability of intranasal Z-LIG pretreatment to enhance protection against neuronal damage i...
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| Veröffentlicht in: | Journal of agricultural and food chemistry 2017-03, Vol.65 (8), p.1533-1542 |
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| container_title | Journal of agricultural and food chemistry |
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| creator | Li, Juan Yu, Jie Ma, Hui Yang, Na Li, Li Zheng, Ding-ding Wu, Ming-xia Zhao, Zhi-long Qi, Hong-yi |
| description | Z-Ligustilide (Z-LIG) is a major component in Rhizoma Chuanxiong, which has been traditionally used as a health food supplement for the prevention of cerebrovascular disease in China. This study investigates the ability of intranasal Z-LIG pretreatment to enhance protection against neuronal damage in rats with middle cerebral artery occlusion (MCAO) and the role of cellular stress response mechanisms Nrf2 and HSP70. Z-LIG significantly mitigated infarct volume, neurological dysfunction, blood–brain barrier disruption, and brain edema (p < 0.01). Moreover, Z-LIG prevented the loss of collagen IV, occludin, and ZO-1 (p < 0.05) and decreased MMP-2 and -9 levels (p < 0.01). Meanwhile, Z-LIG up-regulated NQO1 and HSP70. Notably, blockage of Nrf2-driven transcription or down-regulation of HSP70 remarkably attenuated the preventive effect of Z-LIG (p < 0.05). Together, intranasal delivery of Z-LIG enhanced protection against ischemic injury via Nrf2 and HSP70 signaling pathways and has prophylactic potential in the population at high risk of stroke. |
| doi_str_mv | 10.1021/acs.jafc.6b04979 |
| format | Article |
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This study investigates the ability of intranasal Z-LIG pretreatment to enhance protection against neuronal damage in rats with middle cerebral artery occlusion (MCAO) and the role of cellular stress response mechanisms Nrf2 and HSP70. Z-LIG significantly mitigated infarct volume, neurological dysfunction, blood–brain barrier disruption, and brain edema (p < 0.01). Moreover, Z-LIG prevented the loss of collagen IV, occludin, and ZO-1 (p < 0.05) and decreased MMP-2 and -9 levels (p < 0.01). Meanwhile, Z-LIG up-regulated NQO1 and HSP70. Notably, blockage of Nrf2-driven transcription or down-regulation of HSP70 remarkably attenuated the preventive effect of Z-LIG (p < 0.05). Together, intranasal delivery of Z-LIG enhanced protection against ischemic injury via Nrf2 and HSP70 signaling pathways and has prophylactic potential in the population at high risk of stroke.</description><identifier>ISSN: 0021-8561</identifier><identifier>EISSN: 1520-5118</identifier><identifier>DOI: 10.1021/acs.jafc.6b04979</identifier><identifier>PMID: 28169530</identifier><language>eng</language><publisher>United States: American Chemical Society</publisher><subject>4-Butyrolactone - administration & dosage ; 4-Butyrolactone - analogs & derivatives ; 4-Butyrolactone - chemistry ; Administration, Intranasal ; Animals ; Blood-Brain Barrier - metabolism ; Brain Ischemia - genetics ; Brain Ischemia - metabolism ; Brain Ischemia - prevention & control ; Drugs, Chinese Herbal - administration & dosage ; Drugs, Chinese Herbal - chemistry ; HSP70 Heat-Shock Proteins - genetics ; HSP70 Heat-Shock Proteins - metabolism ; Humans ; Male ; Neuroprotective Agents - administration & dosage ; NF-E2-Related Factor 2 - genetics ; NF-E2-Related Factor 2 - metabolism ; Rats, Sprague-Dawley ; Rhizome - chemistry ; Signal Transduction - drug effects</subject><ispartof>Journal of agricultural and food chemistry, 2017-03, Vol.65 (8), p.1533-1542</ispartof><rights>Copyright © 2017 American Chemical Society</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a336t-5804f5f9523abb1ffd15e51557a4b519ca68a0a8e6b230f03f8bd59f9e098fb93</citedby><cites>FETCH-LOGICAL-a336t-5804f5f9523abb1ffd15e51557a4b519ca68a0a8e6b230f03f8bd59f9e098fb93</cites><orcidid>0000-0003-0564-3892</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/acs.jafc.6b04979$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/acs.jafc.6b04979$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>315,781,785,2766,27078,27926,27927,56740,56790</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28169530$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Juan</creatorcontrib><creatorcontrib>Yu, Jie</creatorcontrib><creatorcontrib>Ma, Hui</creatorcontrib><creatorcontrib>Yang, Na</creatorcontrib><creatorcontrib>Li, Li</creatorcontrib><creatorcontrib>Zheng, Ding-ding</creatorcontrib><creatorcontrib>Wu, Ming-xia</creatorcontrib><creatorcontrib>Zhao, Zhi-long</creatorcontrib><creatorcontrib>Qi, Hong-yi</creatorcontrib><title>Intranasal Pretreatment with Z‑Ligustilide, the Main Volatile Component of Rhizoma Chuanxiong, Confers Prophylaxis against Cerebral Ischemia via Nrf2 and HSP70 Signaling Pathways</title><title>Journal of agricultural and food chemistry</title><addtitle>J. Agric. Food Chem</addtitle><description>Z-Ligustilide (Z-LIG) is a major component in Rhizoma Chuanxiong, which has been traditionally used as a health food supplement for the prevention of cerebrovascular disease in China. This study investigates the ability of intranasal Z-LIG pretreatment to enhance protection against neuronal damage in rats with middle cerebral artery occlusion (MCAO) and the role of cellular stress response mechanisms Nrf2 and HSP70. Z-LIG significantly mitigated infarct volume, neurological dysfunction, blood–brain barrier disruption, and brain edema (p < 0.01). Moreover, Z-LIG prevented the loss of collagen IV, occludin, and ZO-1 (p < 0.05) and decreased MMP-2 and -9 levels (p < 0.01). Meanwhile, Z-LIG up-regulated NQO1 and HSP70. Notably, blockage of Nrf2-driven transcription or down-regulation of HSP70 remarkably attenuated the preventive effect of Z-LIG (p < 0.05). Together, intranasal delivery of Z-LIG enhanced protection against ischemic injury via Nrf2 and HSP70 signaling pathways and has prophylactic potential in the population at high risk of stroke.</description><subject>4-Butyrolactone - administration & dosage</subject><subject>4-Butyrolactone - analogs & derivatives</subject><subject>4-Butyrolactone - chemistry</subject><subject>Administration, Intranasal</subject><subject>Animals</subject><subject>Blood-Brain Barrier - metabolism</subject><subject>Brain Ischemia - genetics</subject><subject>Brain Ischemia - metabolism</subject><subject>Brain Ischemia - prevention & control</subject><subject>Drugs, Chinese Herbal - administration & dosage</subject><subject>Drugs, Chinese Herbal - chemistry</subject><subject>HSP70 Heat-Shock Proteins - genetics</subject><subject>HSP70 Heat-Shock Proteins - metabolism</subject><subject>Humans</subject><subject>Male</subject><subject>Neuroprotective Agents - administration & dosage</subject><subject>NF-E2-Related Factor 2 - genetics</subject><subject>NF-E2-Related Factor 2 - metabolism</subject><subject>Rats, Sprague-Dawley</subject><subject>Rhizome - chemistry</subject><subject>Signal Transduction - drug effects</subject><issn>0021-8561</issn><issn>1520-5118</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kcGO0zAQhi0EYrsLd07IRw5tsZM6cY4oArZSgYoFDlyiSTJOvErsru2w2z3xCrwLT8ST4NLCjYM1kvX930jzE_KMsyVnCX8JjV9eg2qWWc1WRV48IDMuErYQnMuHZMYis5Ai42fk3PtrxpgUOXtMzhLJs0KkbEZ-rk1wYMDDQLcOg0MII5pAb3Xo6ddf339sdDf5oAfd4pyGHuk70IZ-sQPET6SlHXfWHBJW0Y-9vrcj0LKfwNxpa7p5BIxC56Pd7vr9AHfaU-iiwwdaosPaxdVr3_Q4aqDf4nvvVELBtPTyapszeqU7A4M2Hd1C6G9h75-QRwoGj09P84J8fvP6U3m52Hx4uy5fbRaQpllYCMlWSqhCJCnUNVeq5QIFFyKHVS140UAmgYHErE5SpliqZN2KQhXICqnqIr0gL47enbM3E_pQjdo3OAxg0E6-4jITkucsSyPKjmjjrPcOVbVzegS3rzirDl1Vsavq0FV16ipGnp_sUz1i-y_wt5wIzI_An6idXDyD_7_vN38JpBg</recordid><startdate>20170301</startdate><enddate>20170301</enddate><creator>Li, Juan</creator><creator>Yu, Jie</creator><creator>Ma, Hui</creator><creator>Yang, Na</creator><creator>Li, Li</creator><creator>Zheng, Ding-ding</creator><creator>Wu, Ming-xia</creator><creator>Zhao, Zhi-long</creator><creator>Qi, Hong-yi</creator><general>American Chemical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-0564-3892</orcidid></search><sort><creationdate>20170301</creationdate><title>Intranasal Pretreatment with Z‑Ligustilide, the Main Volatile Component of Rhizoma Chuanxiong, Confers Prophylaxis against Cerebral Ischemia via Nrf2 and HSP70 Signaling Pathways</title><author>Li, Juan ; Yu, Jie ; Ma, Hui ; Yang, Na ; Li, Li ; Zheng, Ding-ding ; Wu, Ming-xia ; Zhao, Zhi-long ; Qi, Hong-yi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a336t-5804f5f9523abb1ffd15e51557a4b519ca68a0a8e6b230f03f8bd59f9e098fb93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>4-Butyrolactone - administration & dosage</topic><topic>4-Butyrolactone - analogs & derivatives</topic><topic>4-Butyrolactone - chemistry</topic><topic>Administration, Intranasal</topic><topic>Animals</topic><topic>Blood-Brain Barrier - metabolism</topic><topic>Brain Ischemia - genetics</topic><topic>Brain Ischemia - metabolism</topic><topic>Brain Ischemia - prevention & control</topic><topic>Drugs, Chinese Herbal - administration & dosage</topic><topic>Drugs, Chinese Herbal - chemistry</topic><topic>HSP70 Heat-Shock Proteins - genetics</topic><topic>HSP70 Heat-Shock Proteins - metabolism</topic><topic>Humans</topic><topic>Male</topic><topic>Neuroprotective Agents - administration & dosage</topic><topic>NF-E2-Related Factor 2 - genetics</topic><topic>NF-E2-Related Factor 2 - metabolism</topic><topic>Rats, Sprague-Dawley</topic><topic>Rhizome - chemistry</topic><topic>Signal Transduction - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Juan</creatorcontrib><creatorcontrib>Yu, Jie</creatorcontrib><creatorcontrib>Ma, Hui</creatorcontrib><creatorcontrib>Yang, Na</creatorcontrib><creatorcontrib>Li, Li</creatorcontrib><creatorcontrib>Zheng, Ding-ding</creatorcontrib><creatorcontrib>Wu, Ming-xia</creatorcontrib><creatorcontrib>Zhao, Zhi-long</creatorcontrib><creatorcontrib>Qi, Hong-yi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of agricultural and food chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Juan</au><au>Yu, Jie</au><au>Ma, Hui</au><au>Yang, Na</au><au>Li, Li</au><au>Zheng, Ding-ding</au><au>Wu, Ming-xia</au><au>Zhao, Zhi-long</au><au>Qi, Hong-yi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intranasal Pretreatment with Z‑Ligustilide, the Main Volatile Component of Rhizoma Chuanxiong, Confers Prophylaxis against Cerebral Ischemia via Nrf2 and HSP70 Signaling Pathways</atitle><jtitle>Journal of agricultural and food chemistry</jtitle><addtitle>J. Agric. Food Chem</addtitle><date>2017-03-01</date><risdate>2017</risdate><volume>65</volume><issue>8</issue><spage>1533</spage><epage>1542</epage><pages>1533-1542</pages><issn>0021-8561</issn><eissn>1520-5118</eissn><abstract>Z-Ligustilide (Z-LIG) is a major component in Rhizoma Chuanxiong, which has been traditionally used as a health food supplement for the prevention of cerebrovascular disease in China. This study investigates the ability of intranasal Z-LIG pretreatment to enhance protection against neuronal damage in rats with middle cerebral artery occlusion (MCAO) and the role of cellular stress response mechanisms Nrf2 and HSP70. Z-LIG significantly mitigated infarct volume, neurological dysfunction, blood–brain barrier disruption, and brain edema (p < 0.01). Moreover, Z-LIG prevented the loss of collagen IV, occludin, and ZO-1 (p < 0.05) and decreased MMP-2 and -9 levels (p < 0.01). Meanwhile, Z-LIG up-regulated NQO1 and HSP70. Notably, blockage of Nrf2-driven transcription or down-regulation of HSP70 remarkably attenuated the preventive effect of Z-LIG (p < 0.05). Together, intranasal delivery of Z-LIG enhanced protection against ischemic injury via Nrf2 and HSP70 signaling pathways and has prophylactic potential in the population at high risk of stroke.</abstract><cop>United States</cop><pub>American Chemical Society</pub><pmid>28169530</pmid><doi>10.1021/acs.jafc.6b04979</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0003-0564-3892</orcidid></addata></record> |
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| ispartof | Journal of agricultural and food chemistry, 2017-03, Vol.65 (8), p.1533-1542 |
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| subjects | 4-Butyrolactone - administration & dosage 4-Butyrolactone - analogs & derivatives 4-Butyrolactone - chemistry Administration, Intranasal Animals Blood-Brain Barrier - metabolism Brain Ischemia - genetics Brain Ischemia - metabolism Brain Ischemia - prevention & control Drugs, Chinese Herbal - administration & dosage Drugs, Chinese Herbal - chemistry HSP70 Heat-Shock Proteins - genetics HSP70 Heat-Shock Proteins - metabolism Humans Male Neuroprotective Agents - administration & dosage NF-E2-Related Factor 2 - genetics NF-E2-Related Factor 2 - metabolism Rats, Sprague-Dawley Rhizome - chemistry Signal Transduction - drug effects |
| title | Intranasal Pretreatment with Z‑Ligustilide, the Main Volatile Component of Rhizoma Chuanxiong, Confers Prophylaxis against Cerebral Ischemia via Nrf2 and HSP70 Signaling Pathways |
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