TGF-beta 1 and IL-10 modulate IL-1 beta-induced membrane and soluble ICAM-1 in human myoblasts
We have previously shown that interleukin (IL)-1 beta and other inflammatory cytokines are able to induce the expression of membrane and soluble intercellular adhesion molecule (ICAM)-1 on human myoblasts. In this paper we found that IL-10 and transforming growth factor (TGF)-beta 1 are able to prev...
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| Veröffentlicht in: | Journal of neuroimmunology 2003-01, Vol.134 (1-2), p.151-157 |
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| container_title | Journal of neuroimmunology |
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| creator | Marino, Mariapaola Scuderi, Flavia Mannella, Francesca Bartoccioni, Emanuela |
| description | We have previously shown that interleukin (IL)-1 beta and other inflammatory cytokines are able to induce the expression of membrane and soluble intercellular adhesion molecule (ICAM)-1 on human myoblasts. In this paper we found that IL-10 and transforming growth factor (TGF)-beta 1 are able to prevent IL-1 beta-induced membrane and soluble ICAM-1 protein expression on human myoblasts, with different time courses. The effect of both cytokines is associated to a reduction in ICAM-1 mRNA. Our findings suggest that IL-10 and TGF-beta 1 are able to influence the inflammatory process in muscle tissue at least in part by means of control of membrane and soluble ICAM-1. |
| doi_str_mv | 10.1016/S0165-5728(02)00399-5 |
| format | Article |
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Our findings suggest that IL-10 and TGF-beta 1 are able to influence the inflammatory process in muscle tissue at least in part by means of control of membrane and soluble ICAM-1.</description><subject>Cell Membrane - drug effects</subject><subject>Cell Membrane - immunology</subject><subject>Cell Membrane - metabolism</subject><subject>Cells, Cultured</subject><subject>Down-Regulation - drug effects</subject><subject>Down-Regulation - immunology</subject><subject>Graft Rejection - immunology</subject><subject>Graft Rejection - metabolism</subject><subject>Graft Rejection - physiopathology</subject><subject>Humans</subject><subject>Intercellular Adhesion Molecule-1 - genetics</subject><subject>Intercellular Adhesion Molecule-1 - immunology</subject><subject>Intercellular Adhesion Molecule-1 - metabolism</subject><subject>Interleukin-1 - immunology</subject><subject>Interleukin-1 - metabolism</subject><subject>Interleukin-10 - immunology</subject><subject>Interleukin-10 - metabolism</subject><subject>Interleukin-10 - pharmacology</subject><subject>Muscle Cells - drug effects</subject><subject>Muscle Cells - immunology</subject><subject>Muscle Cells - metabolism</subject><subject>Muscle, Skeletal - immunology</subject><subject>Muscle, Skeletal - metabolism</subject><subject>Muscle, Skeletal - physiopathology</subject><subject>Myoblasts, Skeletal - drug effects</subject><subject>Myoblasts, Skeletal - immunology</subject><subject>Myoblasts, Skeletal - metabolism</subject><subject>Myositis - immunology</subject><subject>Myositis - metabolism</subject><subject>Myositis - physiopathology</subject><subject>Reaction Time - drug effects</subject><subject>Reaction Time - immunology</subject><subject>RNA, Messenger - drug effects</subject><subject>RNA, Messenger - metabolism</subject><subject>Transforming Growth Factor beta - immunology</subject><subject>Transforming Growth Factor beta - metabolism</subject><subject>Transforming Growth Factor beta - pharmacology</subject><subject>Transforming Growth Factor beta1</subject><issn>0165-5728</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kMFOwzAMhnMAsTF4BFBOCA6BuGma9IgmNpCKODCuVEmaiKKkHU1z2NtTxuDiX7Y__7KN0AXQW6BQ3L1OgRMuMnlNsxtKWVkSfoTm_-UZOo3xk1LgLC9P0AwyToWQbI7eN-sV0XZUGLDqGvxUEaA49E3yarT7FP-0Sds1ydgGBxv0oDq7p2Pvk_YTtrx_nsC2wx8pqA6HXa-9imM8Q8dO-WjPD7pAb6uHzfKRVC_raagiWxB0JJZnUhaSQy6VVtqposwccNMoXto8Z4pK5qQ2zuYAwhnpSm4MOCoykWvN2QJd_fpuh_4r2TjWoY3Gej9t2qdYgyw4l9PFC3R5AJMOtqm3QxvUsKv_PsK-AdfmX24</recordid><startdate>200301</startdate><enddate>200301</enddate><creator>Marino, Mariapaola</creator><creator>Scuderi, Flavia</creator><creator>Mannella, Francesca</creator><creator>Bartoccioni, Emanuela</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7T5</scope><scope>7TK</scope><scope>H94</scope></search><sort><creationdate>200301</creationdate><title>TGF-beta 1 and IL-10 modulate IL-1 beta-induced membrane and soluble ICAM-1 in human myoblasts</title><author>Marino, Mariapaola ; Scuderi, Flavia ; Mannella, Francesca ; Bartoccioni, Emanuela</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p170t-e5288685148ababfa692f15cda59e443a083f8bcfe4117fc8f95cc1f07274bb53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Cell Membrane - drug effects</topic><topic>Cell Membrane - immunology</topic><topic>Cell Membrane - metabolism</topic><topic>Cells, Cultured</topic><topic>Down-Regulation - drug effects</topic><topic>Down-Regulation - immunology</topic><topic>Graft Rejection - immunology</topic><topic>Graft Rejection - metabolism</topic><topic>Graft Rejection - physiopathology</topic><topic>Humans</topic><topic>Intercellular Adhesion Molecule-1 - genetics</topic><topic>Intercellular Adhesion Molecule-1 - immunology</topic><topic>Intercellular Adhesion Molecule-1 - metabolism</topic><topic>Interleukin-1 - immunology</topic><topic>Interleukin-1 - metabolism</topic><topic>Interleukin-10 - immunology</topic><topic>Interleukin-10 - metabolism</topic><topic>Interleukin-10 - pharmacology</topic><topic>Muscle Cells - drug effects</topic><topic>Muscle Cells - immunology</topic><topic>Muscle Cells - metabolism</topic><topic>Muscle, Skeletal - immunology</topic><topic>Muscle, Skeletal - metabolism</topic><topic>Muscle, Skeletal - physiopathology</topic><topic>Myoblasts, Skeletal - drug effects</topic><topic>Myoblasts, Skeletal - immunology</topic><topic>Myoblasts, Skeletal - metabolism</topic><topic>Myositis - immunology</topic><topic>Myositis - metabolism</topic><topic>Myositis - physiopathology</topic><topic>Reaction Time - drug effects</topic><topic>Reaction Time - immunology</topic><topic>RNA, Messenger - drug effects</topic><topic>RNA, Messenger - metabolism</topic><topic>Transforming Growth Factor beta - immunology</topic><topic>Transforming Growth Factor beta - metabolism</topic><topic>Transforming Growth Factor beta - pharmacology</topic><topic>Transforming Growth Factor beta1</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Marino, Mariapaola</creatorcontrib><creatorcontrib>Scuderi, Flavia</creatorcontrib><creatorcontrib>Mannella, Francesca</creatorcontrib><creatorcontrib>Bartoccioni, Emanuela</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Journal of neuroimmunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Marino, Mariapaola</au><au>Scuderi, Flavia</au><au>Mannella, Francesca</au><au>Bartoccioni, Emanuela</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>TGF-beta 1 and IL-10 modulate IL-1 beta-induced membrane and soluble ICAM-1 in human myoblasts</atitle><jtitle>Journal of neuroimmunology</jtitle><addtitle>J Neuroimmunol</addtitle><date>2003-01</date><risdate>2003</risdate><volume>134</volume><issue>1-2</issue><spage>151</spage><epage>157</epage><pages>151-157</pages><issn>0165-5728</issn><abstract>We have previously shown that interleukin (IL)-1 beta and other inflammatory cytokines are able to induce the expression of membrane and soluble intercellular adhesion molecule (ICAM)-1 on human myoblasts. In this paper we found that IL-10 and transforming growth factor (TGF)-beta 1 are able to prevent IL-1 beta-induced membrane and soluble ICAM-1 protein expression on human myoblasts, with different time courses. The effect of both cytokines is associated to a reduction in ICAM-1 mRNA. Our findings suggest that IL-10 and TGF-beta 1 are able to influence the inflammatory process in muscle tissue at least in part by means of control of membrane and soluble ICAM-1.</abstract><cop>Netherlands</cop><pmid>12507783</pmid><doi>10.1016/S0165-5728(02)00399-5</doi><tpages>7</tpages></addata></record> |
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| subjects | Cell Membrane - drug effects Cell Membrane - immunology Cell Membrane - metabolism Cells, Cultured Down-Regulation - drug effects Down-Regulation - immunology Graft Rejection - immunology Graft Rejection - metabolism Graft Rejection - physiopathology Humans Intercellular Adhesion Molecule-1 - genetics Intercellular Adhesion Molecule-1 - immunology Intercellular Adhesion Molecule-1 - metabolism Interleukin-1 - immunology Interleukin-1 - metabolism Interleukin-10 - immunology Interleukin-10 - metabolism Interleukin-10 - pharmacology Muscle Cells - drug effects Muscle Cells - immunology Muscle Cells - metabolism Muscle, Skeletal - immunology Muscle, Skeletal - metabolism Muscle, Skeletal - physiopathology Myoblasts, Skeletal - drug effects Myoblasts, Skeletal - immunology Myoblasts, Skeletal - metabolism Myositis - immunology Myositis - metabolism Myositis - physiopathology Reaction Time - drug effects Reaction Time - immunology RNA, Messenger - drug effects RNA, Messenger - metabolism Transforming Growth Factor beta - immunology Transforming Growth Factor beta - metabolism Transforming Growth Factor beta - pharmacology Transforming Growth Factor beta1 |
| title | TGF-beta 1 and IL-10 modulate IL-1 beta-induced membrane and soluble ICAM-1 in human myoblasts |
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