Bioreductive GDEPT using cytochrome P450 3A4 in combination with AQ4N

The bioreductive drug, AQ4N, is metabolized under hypoxic conditions and has been shown to enhance the antitumor effects of radiation and chemotherapy drugs. We have investigated the role of cytochrome P 450 3A4 (CYP3A4) in increasing the metabolism of AQ4N using a gene-directed enzyme prodrug thera...

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Veröffentlicht in:	Cancer gene therapy 2003-01, Vol.10 (1), p.40-48
Hauptverfasser:	McCarthy, Helen O, Yakkundi, Anita, McErlane, Verna, Hughes, Ciara M, Keilty, Gillian, Murray, Margaret, Patterson, Laurence H, Hirst, David G, McKeown, Stephanie R, Robson, Tracy
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anthraquinones - metabolism Anthraquinones - pharmacology Antineoplastic Agents - metabolism Antineoplastic Agents - pharmacology Biomedical and Life Sciences Biomedicine Biotransformation Blotting, Western Cancer Care and treatment Cell Hypoxia Combined Modality Therapy Comet Assay Cytochrome P-450 Cytochrome P-450 CYP3A Cytochrome P-450 Enzyme System - genetics DNA Damage - drug effects DNA Damage - radiation effects DNA, Neoplasm - drug effects Dosage and administration Drug therapy, Combination Fibrosarcoma - enzymology Fibrosarcoma - therapy Gene Expression Gene Therapy Genetic Therapy - methods Health aspects Humans Methods Mice Mice, Inbred C3H NADPH-Ferrihemoprotein Reductase - genetics original-article Prodrugs Prodrugs - metabolism Prodrugs - pharmacology Radiation Dosage Transfection Tumor Stem Cell Assay
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