Nasal Drug Absorption from Powder Formulations: Effect of Fluid Volume Changes on the Mucosal Surface

The effect of changes in the mucosal fluid volume on the nasal drug absorption of powder formulations was evaluated using warfarin (WF), piroxicam (PXC), and norfloxacin (NFX) as model drugs. Lactose and sodium chloride (NaCl), which are water soluble and small-sized chemicals that increase osmotic...

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Veröffentlicht in:	Biological & pharmaceutical bulletin 2017/02/01, Vol.40(2), pp.212-219
Hauptverfasser:	Tanaka, Akiko, Furubayashi, Tomoyuki, Enomura, Yuki, Hori, Tomoki, Shimomura, Rina, Maeda, Chiaki, Kimura, Shunsuke, Inoue, Daisuke, Kusamori, Kosuke, Katsumi, Hidemasa, Sakane, Toshiyasu, Yamamoto, Akira
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Intranasal Animals Chemistry, Pharmaceutical Dogs Excipients - administration & dosage Excipients - chemistry Excipients - metabolism Humans lactose Madin Darby Canine Kidney Cells Male mucociliary clearance Nasal Absorption - drug effects Nasal Absorption - physiology nasal drug absorption Nasal Mucosa - drug effects Nasal Mucosa - metabolism nasal residence osmotic pressure powder formulation Powders Rats Rats, Wistar Transendothelial and Transepithelial Migration - drug effects Transendothelial and Transepithelial Migration - physiology
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