Hydroxysafflor Yellow A Alleviates Lipopolysaccharide-Induced Acute Respiratory Distress Syndrome in Mice

Hydroxysafflor yellow A (HSYA) is an effective ingredient of the Chinese herb Carthamus tinctorius L. The present study investigated the protective effect of HSYA on lipopolysaccharide (LPS)-induced acute respiratory distress syndrome in mice, and the underlying mechanisms involved. HSYA (14, 28, 56...

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Veröffentlicht in:	Biological & pharmaceutical bulletin 2017/02/01, Vol.40(2), pp.135-144
Hauptverfasser:	Zhang, Yadan, Song, Lijuan, Pan, Ruiyan, Gao, Jianwei, Zang, Bao-xia, Jin, Ming
Format:	Artikel
Sprache:	eng
Schlagworte:	A549 Cells Actin Animals Body weight Body weight loss Carthamus tinctorius Chalcone - analogs & derivatives Chalcone - isolation & purification Chalcone - therapeutic use Collagen collagen deposition Dose-Response Relationship, Drug Flow cytometry Fluorescein isothiocyanate Humans hydroxysafflor yellow A Immunohistochemistry Interleukin 6 lipopolysaccharide (LPS) Lipopolysaccharides Lipopolysaccharides - toxicity Lungs Male Mice Mice, Inbred C57BL mRNA Plant Extracts - isolation & purification Plant Extracts - therapeutic use Polymerase chain reaction pulmonary inflammation Quinones - isolation & purification Quinones - therapeutic use Respiratory distress syndrome Respiratory Distress Syndrome, Adult - chemically induced Respiratory Distress Syndrome, Adult - drug therapy Respiratory Distress Syndrome, Adult - pathology Respiratory therapy Rodents Smooth muscle Tissues TLR4 protein toll-like receptor 4 (TLR4) Toll-like receptors Transforming growth factor Transforming growth factor-b1 Tumor necrosis factor Tumor necrosis factor-TNF Umbilical vein
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