Synthesis of Linezolid Metabolites PNU-142300 and PNU-142586 toward the Exploration of Metabolite-Related Events

Linezolid (1) is an oxazolidinone antibiotic that is partially metabolized in vivo via ring cleavage of its morpholine moiety to mainly form two metabolites, PNU-142300 (2) and PNU-142586 (3). It is supposed that accumulation of 2 and 3 in patients with renal insufficiency may cause thrombocytopenia...

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Veröffentlicht in:	Chemical & pharmaceutical bulletin 2017/02/01, Vol.65(2), pp.194-199
Hauptverfasser:	Hanaya, Kengo, Matsumoto, Kazuaki, Yokoyama, Yuta, Kizu, Junko, Shoji, Mitsuru, Sugai, Takeshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Accumulation Kidneys Linezolid Linezolid - analogs & derivatives Linezolid - chemical synthesis Linezolid - metabolism metabolite Metabolites oxazolidinone Renal insufficiency Side effects tetrabutylammonium salt Thrombocytopenia
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