Optimized Translocator Protein Ligand for Optical Molecular Imaging and Screening

Translocator protein (TSPO) is a validated target for molecular imaging of a variety of human diseases and disorders. Given its involvement in cholesterol metabolism, TSPO expression is commonly elevated in solid tumors, including glioma, colorectal cancer, and breast cancer. TSPO ligands capable of...

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Veröffentlicht in:	Bioconjugate chemistry 2017-04, Vol.28 (4), p.1016-1023
Hauptverfasser:	Li, Jun, Smith, Jarrod A, Dawson, Eric S, Fu, Allie, Nickels, Michael L, Schulte, Michael L, Manning, H. Charles
Format:	Artikel
Sprache:	eng
Schlagworte:	Affinity Animals Binding Biological effects Brain tumors Breast cancer Cancer Cell Line, Tumor Cells Chemical synthesis Cholesterol Colorectal carcinoma Computer applications Drug discovery Fluorescence Glioma Humans Ligands Lipid metabolism Medical imaging Metabolism Microscopy, Confocal Models, Molecular Molecular Imaging Optical Imaging Protein Binding Proteins Rats Receptors, GABA - analysis Receptors, GABA - metabolism Solid tumors Tracers
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