MAP(K)ing the Path to Stem Cell Quiescence and the Elusive Enteroendocrine Cell

MAP(K)ing the Path to Stem Cell Quiescence and the Elusive Enteroendocrine Cell

The existence and interaction of proliferating and quiescent intestinal stem cells have been debated since their discovery in the 1970s. In this issue of Cell Stem Cell, using murine intestinal organoids, Basak et al. (2017) induce stem cell quiescence by selective inhibition of EGF/MAPK signaling a...

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Veröffentlicht in:Cell stem cell 2017-02, Vol.20 (2), p.153-154
1. Verfasser: Leedham, Simon J.
Format: Artikel
Sprache:eng
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Animals
Cell Differentiation
Enteroendocrine Cells - cytology
Intestines - cytology
Mice
Organoids - cytology
Stem Cells - cytology
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description The existence and interaction of proliferating and quiescent intestinal stem cells have been debated since their discovery in the 1970s. In this issue of Cell Stem Cell, using murine intestinal organoids, Basak et al. (2017) induce stem cell quiescence by selective inhibition of EGF/MAPK signaling and define culture conditions that direct differentiation to the enteroendocrine lineage. The existence and interaction of proliferating and quiescent intestinal stem cells have been debated since their discovery in the 1970s. In this issue of Cell Stem Cell, using murine intestinal organoids, Basak et al. (2017) induce stem cell quiescence by selective inhibition of EGF/MAPK signaling and define culture conditions that direct differentiation to the enteroendocrine lineage.
doi_str_mv 10.1016/j.stem.2017.01.005
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subjects Animals
Cell Differentiation
Enteroendocrine Cells - cytology
Intestines - cytology
Mice
Organoids - cytology
Stem Cells - cytology
title MAP(K)ing the Path to Stem Cell Quiescence and the Elusive Enteroendocrine Cell
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