PI(3,4,5)P3 Engagement Restricts Akt Activity to Cellular Membranes

Protein kinase B/Akt regulates cellular metabolism, survival, and proliferation in response to hormones and growth factors. Hyperactivation of Akt is frequently observed in cancer, while Akt inactivation is associated with severe diabetes. Here, we investigated the molecular and cellular mechanisms...

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Veröffentlicht in:	Molecular cell 2017-02, Vol.65 (3), p.416-431.e6
Hauptverfasser:	Ebner, Michael, Lučić, Iva, Leonard, Thomas A., Yudushkin, Ivan
Format:	Artikel
Sprache:	eng
Schlagworte:	AGC kinases allostery cellular membranes cellular signaling fluorescence correlation spectroscopy fluorescence cross-correlation spectroscopy phosphatidylinositol-3,4,5-trisphosphate protein kinase B/Akt protein phosphatases signal transduction
Online-Zugang:	Volltext
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