GRN deletion in familial frontotemporal dementia showing association with clinical variability in 3 familial cases

Progranulin (GRN) gene mutations have been genetically associated with frontotemporal dementia (FTD) and are present in about 23% of patients with familial FTD. However, the neurobiology of this secreted glycoprotein remains unclear. Here, we report the identification of 3 pedigrees of Southern Ital...

Ausführliche Beschreibung