Improving drug-like properties of insulin and GLP-1 via molecule design and formulation and improving diabetes management with device & drug delivery

There is an increased incidence of diabetes worldwide. The discovery of insulin revolutionized the management of diabetes, the revelation of glucagon-like peptide-1 (GLP-1) and introduction of GLP-1 receptor agonists to clinical practice was another breakthrough. Continued translational research res...

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Veröffentlicht in:	Advanced drug delivery reviews 2017-03, Vol.112, p.106-122
Hauptverfasser:	Pechenov, Sergei, Bhattacharjee, Himanshu, Yin, Daniel, Mittal, Sachin, Subramony, J. Anand
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Diabetes Diabetes Mellitus, Type 2 - drug therapy Diabetes Mellitus, Type 2 - therapy Drug Compounding Drug Delivery Systems Drug Design Drug-device combination Duration of action GLP-1 stabilization Glucagon-Like Peptide 1 - administration & dosage Glucagon-Like Peptide 1 - chemistry Glucagon-Like Peptide 1 - pharmacology Humans Hypoglycemia Hypoglycemic Agents - administration & dosage Hypoglycemic Agents - therapeutic use Insulin - administration & dosage Insulin - chemistry Insulin - pharmacology Insulin and GLP-1 co-administration Long-acting insulin Onset of action Rapid-acting insulin
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