Clinical predictors of diabetes insipidus after transcranial surgery for pituitary adenoma

Abstract Objective Diabetes insipidus (DI) is a well-known complication of transsphenoidal pituitary adenoma surgery. However, the risk factors for DI after transcranial surgery have not been clarified. In this study, the clinical parameters for predicting DI after transcranial surgery were investigated. Method The perioperative records of 90 patients who underwent transcranial (TC) surgery at the authors’ institution between November 2011 and March 2013 were chosen from 1657 pituitary adenoma patients and retrospectively analyzed. The degree of deformation of the third ventricle and hypothalamus were assessed by preoperative magnetic resonance imaging (MRI). Result Immediate postoperative DI was found in 30 patients (33.3%). Persistent DI was noted in 11 patients (12.6%). Compared with patients in the nonpostoperative DI group, those with postoperative DI had a higher degree of deformation of the third ventricle and hypothalamus (p