Scriptaid enhances skeletal muscle insulin action and cardiac function in obese mice

Aim To determine the effect of Scriptaid, a compound that can replicate aspects of the exercise adaptive response through disruption of the class IIa histone deacetylase (HDAC) corepressor complex, on muscle insulin action in obesity. Materials and methods Diet‐induced obese mice were administered S...

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Veröffentlicht in:	Diabetes, obesity & metabolism obesity & metabolism, 2017-07, Vol.19 (7), p.936-943
Hauptverfasser:	Gaur, Vidhi, Connor, Timothy, Venardos, Kylie, Henstridge, Darren C., Martin, Sheree D., Swinton, Courtney, Morrison, Shona, Aston‐Mourney, Kathryn, Gehrig, Stefan M., van Ewijk, Roelof, Lynch, Gordon S., Febbraio, Mark A., Steinberg, Gregory R., Hargreaves, Mark, Walder, Ken R., McGee, Sean L.
Format:	Artikel
Sprache:	eng
Schlagworte:	animal pharmacology Animals Anti-Obesity Agents - adverse effects Anti-Obesity Agents - therapeutic use Cardiotonic Agents - adverse effects Cardiotonic Agents - therapeutic use Diet, High-Fat - adverse effects Echocardiography Echocardiography, Doppler Energy Metabolism - drug effects Gene Expression Profiling Gene Expression Regulation - drug effects Glucose Heart - diagnostic imaging Heart - drug effects Heart - physiopathology Histone Deacetylase 2 - antagonists & inhibitors Histone Deacetylase 2 - metabolism Histone Deacetylase Inhibitors - adverse effects Histone Deacetylase Inhibitors - therapeutic use Hydroxylamines - adverse effects Hydroxylamines - therapeutic use Insulin Insulin Resistance Male Mice, Inbred C57BL Muscle, Skeletal - drug effects Muscle, Skeletal - metabolism Musculoskeletal system Myocardium - pathology Obesity Obesity - drug therapy Obesity - etiology Obesity - pathology Obesity - physiopathology Organ Size Quinolines - adverse effects Quinolines - therapeutic use Rodents
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