Activation and exhaustion of antigen-specific CD8+ T cells occur in different splenic compartments during infection with Plasmodium berghei

Abstract The spleen is the major organ in which T cells are primed during infection with malaria parasites. However, little is known regarding the dynamics of the immune responses and their localization within the splenic tissue during malaria infection. We examined murine CD8+ T cell responses duri...

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Veröffentlicht in:	Parasitology international 2017-06, Vol.66 (3), p.227-235
Hauptverfasser:	Bayarsaikhan, Ganchimeg, Miyakoda, Mana, Yamamoto, Kazuo, Kimura, Daisuke, Akbari, Masoud, Yuda, Masao, Yui, Katsuyuki
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, Protozoan - genetics Antigens, Protozoan - immunology Apoptosis CD8+ T cells CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - physiology Gastroenterology and Hepatology Immunologic Memory Infectious Disease Infectious diseases Inhibitory receptors Interferon-gamma - immunology Listeria monocytogenes - genetics Listeria monocytogenes - immunology Lymphocyte Activation Malaria Malaria - immunology Malaria - parasitology Mice Mice, Inbred C57BL Ovalbumin - genetics Ovalbumin - immunology Plasmodium berghei - genetics Plasmodium berghei - immunology Spleen Spleen - cytology Spleen - immunology
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