Simultaneous quantification of loxapine, loxapine N-oxide, amoxapine, 8-hydroxyloxapine and 7-hydroxyloxapine in human plasma using LC–MS/MS

Loxapine is an antipsychotic medication used for the treatment of schizophrenia. In vivo, loxapine is metabolized to multiple metabolites. A high performance liquid chromatographic-tandem mass spectrometry (LC–MS/MS) method has been developed and validated for the determination of loxapine and 4 of...

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Veröffentlicht in:	Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Analytical technologies in the biomedical and life sciences, 2017-03, Vol.1046, p.87-97
Hauptverfasser:	Meng, Min, Zhao, Nan, Pederson, Carrie C., Harrison, Edward, Green, Charisse, Gorman, Steven H., Reuschel, Scott
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Antipsychotic Agents - blood Antipsychotic Agents - pharmacokinetics Antipsychotic Agents - therapeutic use Child Chromatography, High Pressure Liquid - methods High performance liquid chromatography and tandem mass spectrometer (HPLC–MS/MS) Human plasma Humans Limit of Detection Linear Models Loxapine Loxapine - analogs & derivatives Loxapine - blood Loxapine - pharmacokinetics Loxapine - therapeutic use Reproducibility of Results Selected reaction monitoring (SRM) Tandem Mass Spectrometry - methods
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