Neuroprotective effects of lycopene in spinal cord injury in rats via antioxidative and anti-apoptotic pathway

•We evaluated the protective effects of lycopene in SCI in rats.•SCI increases oxidative damage.•Oxidative damage can lead to mitochondrial dysfunction and causes cell apoptosis.•Lycopene treatment has a therapeutic potential in oxidative damage-induced mitochondrial dysfunction and cell apoptosis....

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Veröffentlicht in:	Neuroscience letters 2017-03, Vol.642, p.107-112
Hauptverfasser:	Hu, Wei, Wang, Hongbo, Liu, Zhenfeng, Liu, Yanlu, Wang, Rong, Luo, Xiao, Huang, Yifei
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidant Antioxidants - pharmacology Antioxidants - therapeutic use Apoptosis - drug effects Apotosis Carotenoids - pharmacology Carotenoids - therapeutic use Caspases - metabolism Cytochromes b - metabolism DNA-Binding Proteins - metabolism Lycopene Male Malondialdehyde - metabolism Membrane Potential, Mitochondrial - drug effects Mitochondria Mitochondria - metabolism Mitochondrial Proteins - metabolism Neuroprotective Agents - pharmacology Neuroprotective Agents - therapeutic use Oxidative Stress - drug effects Rats Rats, Sprague-Dawley Spinal Cord - drug effects Spinal Cord - metabolism Spinal Cord Injuries - drug therapy Spinal Cord Injuries - metabolism Spinal cord injury Superoxide Dismutase - metabolism Transcription Factors - metabolism
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