Selective transduction of astrocytic and neuronal CNS subpopulations by lentiviral vectors pseudotyped with Chikungunya virus envelope

Abstract Lentiviral vectors are gene delivery vehicles that integrate into the host genome of dividing and non-dividing mammalian cells facilitating long-term transgene expression. Lentiviral vector versatility is greatly increased by incorporating heterologous viral envelope proteins onto the vecto...

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Veröffentlicht in:	Biomaterials 2017-04, Vol.123, p.1-14
Hauptverfasser:	Eleftheriadou, Ioanna, Dieringer, Michael, Poh, Xuan Ying, Sanchez-Garrido, Julia, Gao, Yunan, Sgourou, Argyro, Simmons, Laura E, Mazarakis, Nicholas D
Format:	Artikel
Sprache:	eng
Schlagworte:	Advanced Basic Science Astrocytes - physiology Cell Line Chikungunya virus - genetics CHIKV CNS tropism Dentistry Genetic Vectors - genetics HEK293 Cells HIV-1 Humans Lentiviral vector Lentivirus - genetics Neurons - physiology Pseudotyping SINV Transduction, Genetic - methods Viral Envelope Proteins - genetics VSV
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