Mimicking exercise in three‐dimensional bioengineered skeletal muscle to investigate cellular and molecular mechanisms of physiological adaptation

Bioengineering of skeletal muscle in vitro in order to produce highly aligned myofibres in relevant three dimensional (3D) matrices have allowed scientists to model the in vivo skeletal muscle niche. This review discusses essential experimental considerations for developing bioengineered muscle in o...

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Veröffentlicht in:	Journal of cellular physiology 2018-03, Vol.233 (3), p.1985-1998
Hauptverfasser:	Kasper, Andreas M., Turner, Daniel C., Martin, Neil R. W., Sharples, Adam P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptation Adaptation, Physiological - physiology Bioengineering Bioengineering - methods Bioreactors Cell culture Clinical trials Electric Stimulation electrical stimulation Electrical stimuli Exercise - physiology Humans hypertrophy In vitro methods and tests In vivo methods and tests Mechanical loading Mimicry Molecular modelling Motor neurons Muscle contraction Muscle Contraction - physiology Muscle Development - physiology Muscle Fibers, Skeletal - physiology Muscles Musculoskeletal system myoblasts Perfusion Pharmacology Physiology satellite cells Side effects Skeletal muscle skeletal muscle bioengineering Stimulation Stimuli Stress, Physiological - physiology Studies Three dimensional models Tissue Engineering - methods
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