Higher susceptibility of somatostatin 4 receptor gene-deleted mice to chronic stress-induced behavioral and neuroendocrine alterations

Highlights • Chronic variable stress increases immobility in the tail suspension test in Sstr4-/- mice. • Chronic variable stress decreases the elevated baseline immobility of Sstr4-/- mice in the forced swim test. • Stress-induced increase of Z-scores demonstrating overall HPA-activity is greater i...

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Veröffentlicht in:	Neuroscience 2017-03, Vol.346, p.320-336
Hauptverfasser:	Scheich, Bálint, Csekő, Kata, Borbély, Éva, Ábrahám, István, Csernus, Valér, Gaszner, Balázs, Helyes, Zsuzsanna
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenal Glands - pathology Amygdala - physiopathology Animals Anxiety - physiopathology Behavior, Animal Brain - physiopathology chronic variable stress Corticosterone - blood depression FosB Hippocampus - physiopathology Male Mice Mice, Inbred C57BL Mice, Knockout Motor Activity Neurology Neurons - metabolism Neurosecretory Systems - physiopathology Organ Size Proto-Oncogene Proteins c-fos - metabolism Receptors, Somatostatin - genetics Receptors, Somatostatin - physiology somatostatin somatostatin 4 receptor Stress, Psychological - physiopathology Thymus Gland - pathology
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Zusammenfassung:	Highlights • Chronic variable stress increases immobility in the tail suspension test in Sstr4-/- mice. • Chronic variable stress decreases the elevated baseline immobility of Sstr4-/- mice in the forced swim test. • Stress-induced increase of Z-scores demonstrating overall HPA-activity is greater in Sstr4-/- mice. • FosB expression increases after chronic variable stress in the central and basolateral amygdala in Sstr4-/- mice.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2017.01.039