Intra- and inter-laboratory variation in the scoring of micronuclei and nucleoplasmic bridges in binucleated human lymphocytes: Results of an international slide-scoring exercise by the HUMN project

One of the objectives of the HUman MicroNucleus (HUMN) project is to identify the methodological variables that have an important impact on micronucleus (MN) or micronucleated (MNed) cell frequencies measured in human lymphocytes using the cytokinesis-block micronucleus assay. In a previous study we...

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Veröffentlicht in:	Mutation research 2003-01, Vol.534 (1), p.45-64
Hauptverfasser:	Fenech, Michael, Bonassi, Stefano, Turner, Julie, Lando, Cecilia, Ceppi, Marcello, Chang, Wushou Peter, Holland, Nina, Kirsch-Volders, Micheline, Zeiger, Errol, Bigatti, Maria Paola, Bolognesi, Claudia, Cao, Jia, De Luca, Giuseppe, Di Giorgio, Marina, Ferguson, Lynnette R., Fucic, Aleksandra, Lima, Omar Garcia, Hadjidekova, Valeria V., Hrelia, Patrizia, Jaworska, Alicja, Joksic, Gordana, Krishnaja, A.P., Lee, Tung-Kwang, Martelli, Antonietta, McKay, Michael J., Migliore, Lucia, Mirkova, Ekaterina, Müller, Wolfgang-Ulrich, Odagiri, Youichi, Orsiere, Thierry, Scarfı̀, Maria Rosaria, Silva, Maria J., Sofuni, Toshio, Suralles, Jordi, Trenta, Giorgio, Vorobtsova, Irena, Vral, Anne, Zijno, Andrea
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Biological and medical sciences Cell Nucleus Structures - genetics Diverse techniques DNA damage Fundamental and applied biological sciences. Psychology Human lymphocytes Humans HUMN project International Cooperation Laboratories Lymphocytes - physiology Lymphocytes - radiation effects Male Micronucleus Micronucleus Tests - standards Molecular and cellular biology Nucleoplasmic bridges Observer Variation Poisson Distribution Protocol Reference Standards Scoring Variability
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