Effects of tumor necrosis factor-alpha central administration on hippocampal damage in rat induced by amyloid beta-peptide (25-35)

Male Wistar rats received unilateral intrahippocampal injections of 3 nmol (3.18 μg) aggregated Aβ(25–35), intracerebroventricular bilateral injections of 0.5 μg human recombinant TNFα or both (Aβ(25–35) + TNFα‐treated animals). Seven days after the surgery brain sections were stained with cresyl vi...

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Veröffentlicht in:	Journal of neuroscience research 2003-01, Vol.71 (1), p.110-120
Hauptverfasser:	Stepanichev, Mikhail Yu, Zdobnova, Irina M., Yakovlev, Alexander A., Onufriev, Mikhail V., Lazareva, Natalia A., Zarubenko, Irina I., Gulyaeva, Natalia V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amyloid beta-Peptides - physiology Amyloid beta-Peptides - toxicity amyloid-β peptide (25-35) Animals Astrocytes astroglia Carrier Proteins - drug effects Carrier Proteins - metabolism CASP8 and FADD-Like Apoptosis Regulating Protein Cell Death - drug effects Cerebral Cortex - drug effects Cerebral Cortex - pathology Disease Models, Animal Drug Interactions Functional Laterality Glial Fibrillary Acidic Protein - drug effects Glial Fibrillary Acidic Protein - metabolism Gliosis - chemically induced Gliosis - prevention & control hippocampus Hippocampus - injuries Hippocampus - pathology Immunohistochemistry In Situ Nick-End Labeling Injections, Intraventricular Intracellular Signaling Peptides and Proteins Lectins Male microglia Microglia - metabolism Nerve Degeneration neurodegeneration Peptide Fragments - physiology Peptide Fragments - toxicity Random Allocation Rats Rats, Wistar Recombinant Fusion Proteins - therapeutic use tumor necrosis factor α Tumor Necrosis Factor-alpha - therapeutic use
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