ERCC2/XPD gene polymorphisms and cancer risk

DNA repair of bulky adducts is essential for a normal life, as demonstrated by the existence of rare but dramatic diseases, such as xeroderma pigmentosum (XP), associating DNA repair deficiency and a high cancer proneness. It is plausible that small variations in the efficacy of repair in the normal...

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Veröffentlicht in:	Mutagenesis 2002-11, Vol.17 (6), p.463-469
Hauptverfasser:	Benhamou, Simone, Sarasin, Alain
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences DNA Helicases DNA Repair - genetics DNA-Binding Proteins Fundamental and applied biological sciences. Psychology Humans Models, Genetic Molecular and cellular biology Molecular genetics Mutagenesis. Repair Mutation Neoplasms - etiology Neoplasms - genetics Polymorphism, Genetic Polymorphism, Single Nucleotide Proteins - genetics Risk Factors Skin Neoplasms - genetics Smoking - adverse effects Transcription Factors Xeroderma Pigmentosum - genetics Xeroderma Pigmentosum Group D Protein
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