ATR Regulates Fragile Site Stability

Conditions that partially inhibit DNA replication induce expression of common fragile sites. These sites form gaps and breaks on metaphase chromosomes and are deleted and rearranged in many tumors. Yet, the mechanism of fragile site expression has been elusive. We demonstrate that the replication ch...

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Veröffentlicht in:	Cell 2002-12, Vol.111 (6), p.779-789
Hauptverfasser:	Casper, Anne M., Nghiem, Paul, Arlt, Martin F., Glover, Thomas W.
Format:	Artikel
Sprache:	eng
Schlagworte:	2-Aminopurine - pharmacology Antimetabolites - pharmacology Aphidicolin - pharmacology Ataxia Telangiectasia Mutated Proteins Blotting, Western Caffeine - pharmacology Cell Cycle Proteins - physiology Cells, Cultured Chromosome Fragile Sites Chromosome Fragility Chromosomes - drug effects DNA - biosynthesis DNA-Binding Proteins Dose-Response Relationship, Drug HeLa Cells Humans Metaphase Microscopy, Fluorescence Models, Biological Phosphodiesterase Inhibitors - pharmacology Protein-Serine-Threonine Kinases - metabolism Tumor Suppressor Proteins
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